The authors present an integration of theories concerned with the impact of anxiety, drive, and arousal on schizophrenic processes. They examine (a) anxiety reduction theories, (b) one-factor arousal theories, and (c) twofactor arousal theories. The evidence suggests that it is necessary to consider more than one arousal system to account for schizophrenic disorganization. It is proposed that the physiological correlate of the acute schizophrenic state is a divergence among arousal systems which were formerly in equilibrium. Proposals for future research are suggested in the following areas: (a) Arousal measures in groups and the same schizophrenics in acute, worsened, or recovered conditions; (b) tonic and limbic arousal and relationships, thought organization, premorbid history, diagnosis and clinical course; and (c) experimental measures of clinical anxiety and mood, attention, ego functions, and neurophysiological responses in normals, neurotics, and schizophrenics.