On the relationship of inter-particle cohesiveness and bulk powder behavior: Flowability of pharmaceutical powders

Capece, Maxx; Silva, Karina Ruiz; Sunkara, Divya; Strong, John; Gao, Ping

doi:10.1016/j.ijpharm.2016.06.059

Cited by 66 publications

(37 citation statements)

References 41 publications

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“…Hence, the kaolin powder flow especially increases as the homogeneity of PDS increases, either by the relative reduction of the coarser aggregate fractions, or by cohesiveness of the ultrafine particles (<1 µm), producing uniform sized agglomerates in order to optimize the PSD as indicated by lower span values. Nevertheless, the over-reduction of size increases the inter-particle cohesiveness, the segregation of particles decreases and the flow diminishes [68]. Therefore, the narrower size distribution yields the better flow performance, while the wider size distribution could lead to reduced powder flow and influence the content uniformity during tablet manufacturing.…”

Section: Particle Size Distributionmentioning

confidence: 99%

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients

et al. 2019

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The present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected based on kaolinite richness and their structural order-disorder degree, and after purification, they were dried at 70 • C and heated from room temperature up to 400 • C (10 • C/min). Mineralogy, micromorphology, microtexture, granulometry, porosimetry, moisture content, bulk and tapped density, direct and indirect flowability, and tableting characteristics are studied. Results indicated that purified kaolin samples were made up of 95-99% kaolinite, <3% illite, 1% quartz and 1% anatase. The powder showed mesoporous character (pore diameters from 2 to 38 nm and total pore volume from 0.064 to 0.136 cm 3 /g) with dominance of fine nanosized particles (<1 µm-10 nm). The powder flow characteristics of both the ordered (Hinckley Index HI > 0.7, crystallite size D001 > 30 nm) and disordered (HI < 0.7, D001 < 30 nm) kaolinite-rich samples have been improved (Hausner ratio between 1.24 and 1.09) as their densities were influenced by thermal treatment (with some observed changes in the kaolinite XRD reflection profiles) and by moisture content (variable between 2.98% and 5.82%). The obtained tablets exhibited hardness between 33 and 44 N only from the dehydrated powders at 400 • C, with elastic recovery (ER) between 21.74% and 25.61%, ejection stress (ES) between 7.85 and 11.45 MPa and tensile fracture stress (TFS) between 1.85 and 2.32 MPa, which are strongly correlated with crystallinity (HI) and flowability (HR) parameters. These findings on quality indicators showed the promising pharmaceutical tabletability of the studied Egyptian kaolin powders and the optimization factors for their manufacturability and compactability.

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Section: Particle Size Distributionmentioning

confidence: 99%

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients

et al. 2019

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“…Lactose properties and their connections to DPI performance have been extensively reviewed elsewhere [34,49] and are constantly under investigation. The connection between particle properties and flow behaviour has also been recently reviewed [6,55].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches

Gajjar

Styliari

Nguyen

et al. 2020

International Journal of Pharmaceutics

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“…Everest. Even though a large disparity in the relative size of the roughness element to the particle exists, the behavior of macro‐scale systems that are influenced by van der Waals forces may be sensitive to asperities on the nanometer‐scale due to the change in cohesion magnitude on the particle‐level (examples available elsewhere).…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, much remains unknown about the sensitivity of macro‐scale cohesive behavior to nano‐scale changes in surface roughness. For instance, the effects of roughness on macro‐scale behavior have been limited to van der Waals‐induced cohesion (examples available elsewhere) . However, humidity levels are known to impact the macro‐scale behavior of particles, and roughness has been shown to significantly affect the humidity‐induced (condensed‐capillary) cohesion in particle‐scale experiments, but a direct link between the macro‐scale behavior of particles to changes in surface roughness in humid environments has not been addressed.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, the effects of surface roughness on van der Waals cohesion in macro‐scale systems were investigated by roughening surfaces with nanoparticles (examples available elsewhere). These investigations showed that changes in surface roughness induce measurable changes in the fluid‐mechanical behavior of cohesive granular materials (clustering, shear cell, fluidization, etc.). However, coating surfaces with nanoparticles results in changes to the coefficient of friction, for example, the nanoparticle‐coating typically acts as a lubricant and reduces friction.…”

Section: Introductionmentioning

confidence: 99%

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How nano‐scale roughness impacts the flow of grains influenced by capillary cohesion

et al. 2017

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SignificanceWe show that nano-scale changes in surface roughness affect the macro-scale (many-particle) behavior of granular materials influenced by cohesion. Macro-scale effects of roughness are investigated for conditions where cohesion is dominated by either humidity-induced or van der Waals-induced forces. Surface-topography measurements are used to calculate the relevant interparticle cohesive forces. The (force-dominated) macro-scale cohesion measurements are explained via the ratio of the predicted interparticle cohesive force to gravity, thus reinforcing the importance of roughness to cohesion.The values of u mf plotted in (b) are extracted from (a). Increasing cohesion (via a decrease in roughness or an increase in RH) results in a decrease in the slope of Dp* vs. u in the packed state-such that a statistically significant increase in u mf /u mf,NC is measured between the particles both at dry and humid conditions. Error bars represent 95% confidence intervals, but may be too small to distinguish on the scale of the plot. [Color figure can be viewed at wileyonlinelibrary.com] AIChE Journal

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On the relationship of inter-particle cohesiveness and bulk powder behavior: Flowability of pharmaceutical powders

Cited by 66 publications

References 41 publications

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients

WITHDRAWN: 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches

How nano‐scale roughness impacts the flow of grains influenced by capillary cohesion

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