WITHDRAWN: 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches

Gajjar, Parmesh; Styliari, Ioanna Danai; Nguyen, Tung; Carr, James; Chen, X.; Elliott, James R.; Hammond, R. B.; Burnett, Timothy L.; Withers, Philip J.; Murnane, Darragh

doi:10.1016/j.ijpharm.2019.118988

Cited by 2 publications

(2 citation statements)

References 64 publications

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“…Two blended powder samples were prepared comprising LH100 with 10% w/w LH300 and LH100 with 10% w/w μTBS. These were filled into 2 mm diameter Kapton tube sample holders 47 and scanned using a Zeiss Xradia Versa 520 X-ray microscope using the following settings: voltage 40 kV, power 3 W, source–sample distance 9.0 mm, and sample–detector distance 8.5 mm. A 20× objective and 2× camera binning were used to acquire 1601 projections with an exposure of 12.5 s per projection for each scan.…”

Section: Methodsmentioning

confidence: 99%

Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α-Lactose Monohydrate

Ma,

Nguyen,

Gajjar

et al. 2023

Mol. Pharmaceutics

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Grid-based systematic search methods are used to investigate molecule–molecule, molecule–surface, and surface–surface contributions to interparticle interactions in order to identify the crystal faces that most strongly affect particle behavior during powder blend formulation and delivery processes. The model system comprises terbutaline sulfate (TBS) as an active pharmaceutical ingredient (API) and α-form lactose monohydrate (LMH). A combination of systematic molecular modeling and X-ray computed tomography (XCT) is used to determine not only the adhesive and cohesive interparticle energies but, also the agglomeration behavior during manufacturing and de-agglomeration behavior during delivery after inhalation. This is achieved through a detailed examination of the balance between the adhesive and cohesive energies with the XCT results confirming the blend segregation tendencies, through the particle–particle de-agglomeration process. The results reveal that the cohesive interaction energies of TBS–TBS are higher than the adhesive energies between TBS and LMH, but that the cohesive energies of LMH–LMH are the smallest between molecule and molecule, molecule and surface, and surface and surface. This shows how systematic grid-search molecular modeling along with XCT can guide the digital formulation design of inhalation powders in order to achieve optimum aerosolization and efficacy for inhaled medicines. This will lead to faster pharmaceutical design with less variability, higher quality, and enhanced performance.

show abstract

Section: Methodsmentioning

confidence: 99%

Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α-Lactose Monohydrate

Ma,

Nguyen,

Gajjar

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…17 Only recently, these technologies have been applied to pharmaceutical samples. 18,19,26,30,41 Specifically, our previous publication reported an extensive XRM characterization on a poly (lactic-co-glycolic acid) (PLGA) implant product 20 to correlate formulation parameters and manufacturing conditions with product quality and performance through quantitative microstructure characterization. This paper continues to report our findings using this novel image-based characterization methodology.…”

Section: Introductionmentioning

confidence: 99%

Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study

Zhang

Nagapudi²,

Shen

et al. 2022

Journal of Pharmaceutical Sciences

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WITHDRAWN: 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches

Cited by 2 publications

References 64 publications

Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α-Lactose Monohydrate

Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α-Lactose Monohydrate

Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study

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