This paper presents a new large-scale signer independent dataset for Kazakh-Russian Sign Language (KRSL) for the purposes of Sign Language Processing. We envision it to serve as a new benchmark dataset for performance evaluations of Continuous Sign Language Recognition (CSLR) and Translation (CSLT) tasks. The proposed FluentSigners-50 dataset consists of 173 sentences performed by 50 KRSL signers resulting in 43,250 video samples. Dataset contributors recorded videos in real-life settings on a wide variety of backgrounds using various devices such as smartphones and web cameras. Therefore, distance to the camera, camera angles and aspect ratio, video quality, and frame rates varied for each dataset contributor. Additionally, the proposed dataset contains a high degree of linguistic and inter-signer variability and thus is a better training set for recognizing a real-life sign language. FluentSigners-50 baseline is established using two state-of-the-art methods, Stochastic CSLR and TSPNet. To this end, we carefully prepared three benchmark train-test splits for models’ evaluations in terms of: signer independence, age independence, and unseen sentences. FluentSigners-50 is publicly available at https://krslproject.github.io/FluentSigners-50/