“…MCs react to parasite exposure by releasing their contents through degranulation, a process that has been frequently documented in fish infected with metazoan parasites (Sayyaf Dezfuli et al ., 2021 a ). MC granules contain a panel of inflammation mediators including piscidins (Silphaduang et al ., 2006; Dezfuli et al ., 2010; Salger et al ., 2016), serotonin (Dezfuli et al ., 2000; Da Silva et al ., 2017), mucopolysaccharides with residues of α - N -acetyl-galactosamine (Dezfuli et al ., 2015) and finally, histamines (Mulero et al ., 2008; Salim et al ., 2012; Galindo-Villegas et al ., 2016; Sayyaf Dezfuli et al ., 2018). It is well known that, most parasitic helminths due to their attachment structures and/or penetration in host organ induce damages, and one of the functions of the MCs is tissue repair and remodelling (Dezfuli et al ., 2015).…”