The applications of biogenic lubricating greases to machine elements play important roles in the reduction of friction energy and minimizing wear in a tribological contact, as well as the prevention of environmental pollution. The aim of this work was to investigate completely biogenic lubricating greases from a tribological point of view. Model greases were examined using a ball on a disc tribometer at a constant normal force to investigate the friction and wear process according to Fleischer’s energetic wear model. Using the energy-based wear model, the friction and wear process could be interpreted as a cause–effect sequence. Moreover, the influence of the model grease composition on the friction and wear process was analyzed. In addition, rolling bearing tests were performed to investigate the tribological behaviors of some selected biogenic greases during real machine element contact. These tests allowed for the quantification of the friction torque behavior of the full bearing and the evaluation of the wear obtained through lubricant analysis procedures. This experimental work provides useful information regarding the influence that the composition of biogenic model greases has on friction and wear behaviors in a tribological contact.