The emergence of political neuroscience-an interdisciplinary venture involving political science, psychology, and cognitive neuroscience-has piqued the interests of scholars as well as the mass public. In this chapter, we review evidence pertaining to four areas of inquiry that have generated most of the research in political neuroscience to date: (1) racial prejudice and intergroup relations; (2) the existence of partisan bias and motivated political cognition; (3) the nature of left-right differences in political orientation; and (4) the dimensional structure of political attitudes. Although these topics are well-known to political psychologists, the application of models and methods from neuroscience has renewed interest in each of them and yielded novel insights. There is reason to believe that many other areas of political psychology await similarly promising renewals and that innovative methods will continue to advance our understanding of the physiological processes involved in political cognition, evaluation, judgment, and behavior. We address limitations, criticisms, and potential pitfalls of existing work-including the "chicken-and-egg problem"-and propose an ambitious agenda for the next generation of research in political neuroscience.KEY WORDS: political neuroscience, racial prejudice, partisanship, ideology "It is evident that the state is a creation of nature, and that man is by nature a political animal." -AristotleOne of the most trenchant social and political psychologists of the twentieth century, William J. McGuire (1993), observed that the "politics and psychology relationship has been lively and Advances in Political Psychology, Vol. 35, Suppl. 1, 2014 doi: 10.1111 long-lasting as interdisciplinary affairs go, its longevity fostered by frequent shiftings of its popular topics, methods, and theories" (p. 363; see also Jost & Hardin, 2011). As in all sustainable relationships, psychology and political science have, for the most part, changed together rather than grown apart (e.g., see Huddy, Sears, & Levy, 2013;McGuire, 1993; Sears, Huddy, & Jervis, 2003). Perhaps it was inevitable, then, that political scientists would come to share psychologists' enthusiasm for the models and methods of neuroscience, including the use of electroencephalography (EEG), magnetic resonance imaging (MRI), and other measures of the central and peripheral nervous system (e.g., Amodio, Jost, Master, & Yee, 2007;Carmen, 2007;Fowler & Schreiber, 2008;Schreiber et al., 2013;Smith, Oxley, Hibbing, Alford, & Hibbing, 2011b;Taber & Young, 2013;Theodoridis & Nelson, 2012). Political neuroscience is an interdisciplinary venture that tackles questions of mutual interest to political scientists and psychologists by drawing, at least in part, on the theories, methods, and assumptions of biology, especially neuroscience. The application of neuroscience to political topics offers a powerful set of research methods that promises to integrate multiple levels of analysis. As E. O. Wilson (1998) wrote in Consilience: The Unity of ...