On the Synthesis of Molecularly Imprinted Polymers for Analytical and Sensor Applications

Gkementzoglou, Chrysoula; Kotrotsiou, Olympia; Stoukides, Michael; Kiparissides, Costas

doi:10.1002/masy.201300081

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…This combination of polymerisation reagents has been used in numerous MIP studies for other applications. 9,12,11,14,15,16,17 In this study, MIPs were utilised as selective adsorbents for the solid-phase extraction of selected pesticides from cannabis plant material. To our knowledge, no similar studies have been reported in the literature to date.…”

Section: Introductionmentioning

confidence: 99%

Selective Solid-Phase Extraction Using Molecularly Imprinted Polymers for the Analysis of Target Pesticides in Cannabis Bud

Myburgh

Kemp²,

Forbes

2021

S.Afr.j.chem.

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A molecularly imprinted solid-phase extraction (MISPE) procedure was developed for the GC-MS analysis of four high priority pesticides (atrazine, terbuthylazine, acetochlor and alachlor) in a cannabis bud sample matrix. The study demonstrated that the synthesised polymer had a high affinity and good selectivity for either chloroacetamide or triazine classes of pesticide used as a template molecule during the molecularly imprinted polymerisation reaction. The MISPE procedure was optimised in terms of loading, washing and elution fractions utilising a range of aqueous methanol solutions for optimal recovery and minimal matrix interferences. The optimal wash fraction was 20% (v/v) methanol in an aqueous solution, whilst 70% (v/v) was used for the elution fraction. The selectivity, accuracy and recovery of the MISPEs were verified using a synthesised non-imprinted polymer and a commercial C18 cartridge as reference sorbents in comparative experiments. Approximately 3 g of the cannabis bud sample was spiked at a 0.05 mg/kg maximum residue limit (MRL) concentration. The recovery of the four selected pesticides extracted from the spiked samples ranged between 76.4-85.0% when utilising the optimised MISPE methods, compared to 91.6-96.9% for the C18 SPE. However, the use of the MISPE resulted in enhanced selectivity, as evidenced by GC-MS analysis, due to the extraction of less matrix interferences. Therefore, it can be concluded that the MISPE is a viable pre-treatment method for selective pesticide analysis in cannabis flowers using GC-MS when selectivity is valued for the extraction of target pesticides from a complex sample matrix. Keywords: molecularly imprinted polymer; solid-phase extraction; Cannabis; pesticides; atrazine; terbuthylazine; acetochlor; alachlor

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Section: Introductionmentioning

confidence: 99%

Selective Solid-Phase Extraction Using Molecularly Imprinted Polymers for the Analysis of Target Pesticides in Cannabis Bud

Myburgh

Kemp²,

Forbes

2021

S.Afr.j.chem.

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“…The MIPs can rebind the template with high selectivity due to the complementarity of binding sites and template in shape, size, and functionality . Their high binding affinity, chemical stability, low cost, and easy preparation make them widely used in many applications, such as solid‐phase extraction, chemical sensors, antibody mimics, and drug delivery systems …”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac

Zheng

Wang

Cheng

2018

Polymers for Advanced Techs

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In this study, a series of imprinted poly(methacrylic acid-co-ethylene glycol dimethacrylate) nanocarriers for diclofenac and corresponding nonimprinted polymer nanocarriers have been synthesized in 4 different types of solvents by precipitation polymerization. The products were characterized by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and Brunauer-Emmett-Teller measurement. Results showed that uniformly sized molecularly imprinted polymer (MIP) nanospheres with relatively good porosity could only be obtained in acetonitrile. The effects of solvents on the recognition and release properties of polymer particles were also carefully investigated. The binding experiments indicated that MIPs prepared in acetonitrile displayed much higher binding capacity than other MIPs with a maximum binding capacity of 65.18 mg g −1 . The Scatchard analysis showed that synthetic MIPs have special recognition sites for diclofenac, while nonimprinted polymers have not. The Sips model could provide a best fit to the equilibrium data of nanocarriers over whole concentrations. The experimental data of an adsorption kinetic study were well fitted to the pseudo-second-order kinetic model, indicating the chemisorption mechanism between diclofenac and MIPs in the process of adsorption. The drug release of diclofenac from MIPs could well be described by the Ritger-Peppas model, suggesting a non-Fickian diffusion mechanism. In addition, we successfully used MIPs to extract diclofenac at low levels from fetal bovine serum.

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Development of a sandwich-type filtration unit packed with MIP nanoparticles for removal of atrazine from water sources

Gkementzoglou

Kotrotsiou

Koronaiou

et al. 2016

Chemical Engineering Journal

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On the Synthesis of Molecularly Imprinted Polymers for Analytical and Sensor Applications

Cited by 4 publications

References 15 publications

Selective Solid-Phase Extraction Using Molecularly Imprinted Polymers for the Analysis of Target Pesticides in Cannabis Bud

Selective Solid-Phase Extraction Using Molecularly Imprinted Polymers for the Analysis of Target Pesticides in Cannabis Bud

Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac

Development of a sandwich-type filtration unit packed with MIP nanoparticles for removal of atrazine from water sources

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