This paper is concerned with the identification of the key interactions controlling the deflagration-to-detonation transition in narrow smooth-walled channels. Two agencies contributing to the transition are discussed: hydraulic resistance and flame folding. Depending on the kinetics and parameters of the system, nucleation of detonation may occur near the channel wall and/or in the channel interior. A possibly unexpected outcome of the resistance-folding interplay is the non-monotonicity of the dependence between the predetonation run up time/distance and the channel width.