On the Use of Certain Antiseptic Substances in the Treatment of Infected Wounds

Dakin, H.D.

doi:10.1136/bmj.2.2852.318

Cited by 157 publications

(78 citation statements)

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“…Dakin noted that sodium hypochloride was a very effective germicide but irritating to skin. He found adding boric acid neutralised the solution, making it effective but also non-irritating [20]. In another trial A. Carrel found that the antiseptic action of Dakin's hypochlorite solution was short-lived so had to be renewed frequently [21].…”

Section: Wound Infectionmentioning

confidence: 99%

Infection in a Pre-Antibiotic Era

Runcie¹

2015

J Anc Dis Prev Rem

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Aims: This article is designed to demonstrate the problems of infection in a time without antibiotics and to raise awareness and stimulate discussion about the future and the next steps for managing antibiotic resistance. Methods:Access was gained to original journals and letters of three doctors, who joined the army working as medical officers during the First World War. Transcripts of interviews of the doctors performed after the war, in 1977-1979, were also looked at. These original records were studied and any references to infection were collected. A literature search was then performed to identify research carried out during the First World War on the development of the management of infection and sanitation during that time period. A further literature search was then performed to identify modern day concerns with infection, in particular with regard to antibiotic resistance. Results:The three doctors made many comments about infection in their journals and letters written during the war. It was clearly a major concern in the treatment of injured soldiers and few effective remedies were available. The literature search demonstrated that this concern was worldwide with massive investment in research between 1915 and 1917. This produced a drive of innervation and development, rapidly improving the management of infection during that time. Now, with concerns of rising antibiotic resistance, infection is again becoming a medical challenge that requires a renewed drive to push research forward. Conclusions:This article demonstrates that without effective antibiotics infection is massive medical challenge. However when a problem is identified it is possible to produce rapid solutions with research and development. Antibiotic resistance is on the rise. Further research with international cooperation is now required to ensure a simple wound does not become untreatable condition.

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Section: Wound Infectionmentioning

confidence: 99%

Infection in a Pre-Antibiotic Era

Runcie¹

2015

J Anc Dis Prev Rem

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“…During World War I, the chemist Henry Drysdale Dakin and the surgeon Alexis Carrel used buffered 0.5% NaOCl to wash and disinfect infected wounds, based on Dakin's study of the effectiveness of different solutions on infected necrotic tissues (5,6). …”

Section: Sodium Hypochlorite (Naocl)mentioning

confidence: 99%

Endodontic Irrigation Solutions: A Review

Topbaş

Adıgüzel

2017

Int Dent Res

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The goal of endodontic treatment is to remove all the vital and necrotic tissues, microorganisms and microbial byproducts from root canal system. This goal can be achieved through chemical and mechanical debridement of root canals. This article narrates the specifics and requirements of the irrigation solutions. Sodium hypochlorite is proposed as the primary irrigant by virtue of its organic tissue dissolution capacity and broad antimicrobial properties. On the other hand, chelation solutions are recommended as auxiliary solutions to remove the smear layer or to hinder its formation on dentin surface. Thus, it's hoped that sealers and root canal fillers can penetrate to dentin tubules and obturate the canals hermetically. There are new studies on traditional irrigants especially on some irrigants that can replace sodium hypoclorite. This article reviews the new irrigants which can be used in future endodontic practice, and their advantages and limitations. Moreover, actions and interactions of recently used irrigants are adverted.

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“…Based on the controlled laboratory studies by Koch and Pasteur, hypochlorite then gained wide acceptance as a disinfectant by the end of the 19 th century. In World War I, the chemist Henry Drysdale Dakin and the surgeon Alexis Carrel extended the use of a buffered 0.5% sodium hypochlorite solution to the irrigation of infected wounds, based on Dakin meticulous studies on the efficacy of different solutions on infected necrotic tissue (Dakin, 1915). Besides their wide-spectrum, nonspecific killing efficacy on all microbes, hypochlorite preparations are sporocidal, virucidal , and show far greater tissue dissolving effect on necrotic than on vital tissues ( Austin & Taylor, 1918) .…”

Section: Sodium Hypochloritementioning

confidence: 99%