On the way to a patient table integrated scanner system in magnetic particle imaging

Kaethner, Christian; Ahlborg, Mandy; Gräfe, Ksenija; Bringout, Gaël; Sattel, Timo F.; Buzug, Thorsten M.

doi:10.1117/12.2042765

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…It is to support the maximum level of current to be supplied to the excitation coil at KHz level frequency with least impedance loss in the system and MNPs can be excited maximally from the excitation coil. The bulkiness and connection to extra electronic components should be avoided so that the simplest single-sided MPI scanner can be developed and used for the scanning of the complex human body surface [19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

A simulation study of excitation coil design in single-sided mpi scanner for human body application

Othman¹,

Birahim²,

Zakaria³

et al. 2019

Bulletin EEI

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Magnetic particle imaging (MPI), a tomographic imaging method has been introduced for 3D imaging of human body with some potential applications such as magnetic hyperthermia and cancer imaging. It involves three important elements: tracer development using magnetic nanoparticles (MNPs), hardware realization (scanner using excitation and pickup coils), and image reconstruction optimization. Their combination will produce a high quality of image taken from any biological tissue in the human body based on the secondary magnetic field signal from the magnetized MNPs that are injected into human body. A homogeneous and adequate magnetic field strength from an excitation coil is needed to enhance the quality of the secondary signal. However, the complex surface topography of human body and physical properties of an excitation coil influence the strength and the homogeneity of the magnetic field generation at the MNPs. Therefore, this work focused on finding alternative design of excitation coil used in single sided MPI to produce up to 2 mT with high homogeneity of field distribution in the MNPs at the varied depth of 10 to 30 mm under the excitation coil. We proposed several designs with variation in physical properties and coil arrangement based on simulation study carried out by using Ansys Maxwell.

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Section: Introductionmentioning

confidence: 99%

A simulation study of excitation coil design in single-sided mpi scanner for human body application

Othman¹,

Birahim²,

Zakaria³

et al. 2019

Bulletin EEI

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show abstract

“…Besides optimization of the MNPs, a lot of research is centered on improving the sensitivity and efficiency by proposing new drive-field (DF) and focus-field coil topologies, like the field-free-line coils, elliptical coils, or traveling wave coils [3-6]. In combination with harmonic-space MPI the receive chain often contains a high-order and low-loss band-stop filter (BSF) to suppress the drive field signal component in the receive signal and avoid saturation of the amplifier or the analog-to-digital conversion [7].…”

Section: Introductionmentioning

confidence: 99%

A Field Cancellation Signal Extraction Method for Magnetic Particle Imaging

et al. 2015

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In nowadays Magnetic Particle Imaging (MPI) signal detection and excitation happens at the same time. This concept, however, leads to strong coupling of the drive (excitation) field (DF) with the receive chain. As the induced DF signal is several orders of magnitude higher, special measures have to be taken to suppress this signal portion within the receive signal to keep the required dynamic range of the subsequent analog to digital conversion in a technically feasible range. For "frequency space MPI" high-order band-stop-filters have been successfully used to remove the DF signals, which unfortunately as well removes the fundamental harmonic components of the signal of the magnetic nanoparticles (MNP). According to the Langevin theory the fundamental harmonic component has a large signal contribution and is important for direct reconstruction of the particle concentration. In order to separate the fundamental harmonic component of the MNP from the induced DF signal, different concepts have been proposed using signal cancelation based on additional DF signals, also in combination with additional filtering.In this paper, we propose a field-cancelation (FC) concept in which a receive coil (RC) consists of a series connection of a primary coil in combination with an additional cancelation coil. The geometry of the primary coil was chosen to be sensitive for the MNP signal while the cancelation coil was chosen to minimize the overall inductive coupling of the FC-RC with the DF. Sensitivity plots and mutual coupling coefficients were calculated using a thin-wire approximation. A prototype FC-RC was manufactured and effectiveness of the reduction of the mutual inductive coupling (d) was tested in an existing mouse MPI scanner. The difference between simulations (d s =70 dB) and the measurements (d ms =55 dB) indicated the feasibility as well as the need for further investigations.

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Variability of Excitation Coil Design and Performance in Magnetic Particle Imaging: A Review

Birahim

Othman

Sapuan

et al. 2019

2019 IEEE International Conference on Smart Instrumentation, Measurement and Application (ICSIMA)

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On the way to a patient table integrated scanner system in magnetic particle imaging

Cited by 3 publications

References 20 publications

A simulation study of excitation coil design in single-sided mpi scanner for human body application

A simulation study of excitation coil design in single-sided mpi scanner for human body application

A Field Cancellation Signal Extraction Method for Magnetic Particle Imaging

Variability of Excitation Coil Design and Performance in Magnetic Particle Imaging: A Review

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