Under the trend of global carbon emission reduction and energy transformation, variable renewable energies (VREs mainly wind power and solar) will develop rapidly. Many countries have put forward ambitious VREs development plans, and a high penetration of VREs will have a significant impact on the grid. This paper focuses on the analysis of the influence of the VREs’ penetration on the capacity of transmission lines, establishes an analysis model based on mixed integer optimization and power transfer distribution factors (FTDFs), and uses this model to carry out a quantitative study on a typical system. Through the analysis of the research results, as the penetration rate of VREs increases, the transmission power of the transmission lines and the investment cost of the transmission lines will increase, and the line utilization rate will decrease. Utility companies should pay attention to the impact of future development of VREs on grid investment costs and recovery.