In the present paper, we are concerned with a class of constrained vector optimization problems, where the objective functions and active constraint functions are locally Lipschitz at the referee point. Some second-order constraint qualifications of Zangwill type, Abadie type and Mangasarian -Fromovitz type as well as a regularity condition of Abadie type are proposed in a nonsmooth setting. The connections between these proposed conditions are established. They are applied to develop second-order Karush-Kuhn-Tucker necessary optimality conditions for local (weak, Geoffrion properly) efficient solutions to the considered problem. Examples are also given to illustrate the obtained results.