Once-daily sustained-release matrix tablets of nicorandil: Formulation and in vitro evaluation

Reddy, K. Raghuram; Mutalik, Srinivas; Reddy, Suraj Jayadeva

doi:10.1208/pt040461

Cited by 189 publications

(127 citation statements)

References 12 publications

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“…It is a recommended first-line drugs in the symptomatic treatment of rheumatoid arthritis, Osteoarthritis and ankylosing spondylitis. Aceclofenac, i.e., 2-{2-{2-(2,6-dichlorophenyl)amino}phenyl}acetyl]oxy]acetic acid, has a short biological half life of approx 4 h and a dosing frequency of 200 mg daily in two divided doses [4][5][6]. Consequently, the drug is a good candidate for sustained release formulation.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Ghosh¹,

Barik²

2010

Trop. J. Pharm Res

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Purpose: The objective of the study was to develop matrix tablets for oral controlled release of aceclofenac using ethyl cellulose, guar gum and various grades of cellulose polymers. Methods: Possible drug-excipient interaction was evaluated by high performance liquid chromatography (HPLC) and Fourier infrared spectroscopy (FTIR). The tablets prepared were assessed for their physicochemical, in vitro drug release at pH1.2, 4.5, 6.8 and 7.5 and stability characteristics. Comparison with a 'once daily' commercial aceclofenac product was made in the in vitro studies. Results: There was no interaction between aceclofenac and the polymers used as excipients. Furthermore, the physicochemical properties of the tablets were satisfactory. The release profile of one of the formulated aceclofenac tablets (F7), which contained hydroxypropyl methyl cellulose (HPMC K4M), was statistically similar (p < 0.05) to that of the commercial aceclofenac brand in all the dissolution media. The formulated products ware stable and showed no changes in physical appearance, drug content, or dissolution pattern after storage at 40 o C /75 %RH for 6 months. Conclusion:The results indicate that it is feasible to achieve a stable 'once daily' sustained release aceclofenac tablet formulation by using HPMC K4M of 4000cps viscosity grade as matrix material.

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Section: Introductionmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Ghosh¹,

Barik²

2010

Trop. J. Pharm Res

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“…The amount of MCC incorporated in the matrix tablets may have an effect on the deformation of the polymer particles (average particle size of 305 µm) during compression and therefore affect the porosity of the tablet, with higher MCC concentrations creating a less porous matrix (Tiwari, Dinunzio, Rajabi, 2011). The type of the polymers and the nature of excipients, such as MCC; as well as the physical properties of the granules, such as the specific surface area, shape, and hardness, can significantly affect the rate of dissolution of drugs contained in a formulation (Reddy, Mutalik, Reddy, 2003). In this study, the hardness of all the tablets investigated had no direct effect on drug release.…”

Section: Resultsmentioning

confidence: 99%

In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

Guerra-Ponce

Gracia-Vásquez

González-Barranco

et al. 2016

Braz. J. Pharm. Sci.

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A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethyl cellulose (EC) were prepared using direct compression and the drug content, content uniformity, hardness, friability, dissolution performance, and in vitro release kinetics were examined. Formulated tablets were found to be within acceptable limits for physical and chemical parameters. The release kinetics of the Carbopol®971P 8% formulation showed the best linearity (r 2 =0.977) in fitting zero-order kinetics, suggesting the release rate was time independent. The drug release from tablets containing 8% CP was extended over approximately 18 hours and the release kinetics were nearly linear, suggesting that this system has the potential to maintain constant plasma drug concentrations over 12 hours, which could reduce the frequency of administration and the occurrence of adverse effects associated with repeated administration of conventional IB tablets.Uniterms: Ibuprofen/study. Ibuprofen/sustained release tablets. Ibuprofen/formulation/carbopol. Ibuprofen/formulation/hydroxypropyl methylcellulose. Ibuprofen/formulations/ethyl cellulose. Ibuprofen/ formulations/release kinetics.

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“…The tapped density was determined by using the following formula. [10] Weight of the powder Tapped bulk density Tapped volume of the packing =…”

Section: Densitymentioning

confidence: 99%

“…It was calculated by the following formula. [10] Tapped bulk density Hausner's ratio Loose bulk density =…”

Section: Compressibility Indexmentioning

confidence: 99%

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Kamble¹

2016

AJP

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Aim: The objective of proposed study was to prepare bilayer floating tablet comprising ibuprofen (IB) and pregabalin (PGB) for effective treatment of neuropathic pain. Materials and Methods: IB was formulated as immediate release (IR) layer using disintegrants such as croscarmellose sodium (CCS) and sodium starch glycolate (SSG) whereas PGB was formulated as sustained release (SR) layer using polymers hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M, sodium alginate and for increasing gastric residence time sodium bicarbonate as gas generating agent, with a view to deliver the drug at sustained manner in gastrointestinal tract and consequently into systemic circulation. Tablet blends were evaluated through various pre-compression tests, compressed by wet granulation method and evaluated. Results and Discussion: As fast disintegrant, SSG at 20% concentration produced excellent results by immediately releasing IB to exert its anti-inflammatory analgesic and other additional beneficial effects. K100M grade of HPMC produced excellent SR efficiency at 1:1 drugpolymer ratio whereas sodium bicarbonate based CO 2 gas generating system provides required extended gastric retention of the dosage form for long-lasting effect of the therapeutic agent. Final formulation released 96% drug in 15 min and 98% drug in 24 h, in vitro from respective layers. Conclusion: Pre-compression and postcompression parameters of optimized IR layer comprising IB and floating SR layer comprising PGB exhibit satisfactory results. Bilayer tablet of IB and PGB may prove to be very effective as a combination therapy for the treatment of neuropathic pain by sequential release of the drug.

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Once-daily sustained-release matrix tablets of nicorandil: Formulation and in vitro evaluation

Cited by 189 publications

References 12 publications

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

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