Oncocytic adenomas and oncocytic hyperplasia of salivary glands: a clinicopathological study of 26 cases

Palmer, Tracy; Gleeson, Malachy J.; Eveson, J.W.; Cawson, R.A.

doi:10.1111/j.1365-2559.1990.tb01549.x

Cited by 109 publications

(50 citation statements)

References 15 publications

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“…6 The World Health Organization defines 3 categories of oncocytic neoplasms of the salivary gland. Oncocytoma, the most frequent form, is as a well-circumscribed benign tumor composed of monotonous sheets of oncocytes, frequently with a central scar.…”

Section: Discussionmentioning

confidence: 99%

Parotid Gland Oncocytosis: CT Findings with Histopathologic Correlation

Shellenberger¹,

Williams²,

Kumar³

2008

AJNR Am J Neuroradiol

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SUMMARY:Oncocytic neoplasms result from metabolically altered cells that accumulate abundant mitochondria within their cytoplasm by oncocytic metaplasia. In this report, the CT findings are described and correlated with the histopathologic features of a case of oncocytoma involving the parotid gland that arose in a background of nodular oncocytic hyperplasia. When imaging demonstrates multiple small nodules in the parotid gland with a large, solid, or cystic mass, the diagnosis of oncocytic neoplasia should be considered.O ncocytic neoplasms result from metabolically altered cells that accumulate abundant mitochondria within their cytoplasm to form oncocytes by the process of oncocytic metaplasia. These neoplasms are found rarely in the parotid gland and account for Ͻ1% of salivary gland tumors. However, the finding of oncocytic metaplasia is extremely common and occurs in a multitude of organs, including the thyroid gland, parathyroid glands, and kidneys, in addition to salivary glands.In the parotid gland, oncocytic metaplasia arises along a spectrum of related conditions, including oncocytic hyperplasia, benign oncocytoma, and, rarely, oncocytic carcinoma. Oncocytic hyperplasia may be found in microscopic foci or multiple macroscopic nodules, known as nodular oncocytic hyperplasia. Oncocytoma is a benign tumor comprising bland oncocytes, usually presenting as a single nodule.To our knowledge, the imaging findings of oncocytic metaplasia of the salivary gland have only limited description in the literature. We present the CT and histopathologic findings of a case of oncocytoma arising in a background of oncocytic hyperplasia of the parotid gland. Case ReportA 61-year-old white man presented with a 3-year history of painless right parotid gland fullness. One week prior, he developed sudden constant dull aching pain radiating from the right parotid region. Physical examination revealed diffuse enlargement of the parotid gland with a soft nontender right retromandibular mass. Intraoral examination revealed bulging of the right oropharynx. No facial nerve dysfunction or cervical lymphadenopathy was found.CT revealed enlargement of the superficial lobe and loss of normal architecture of the right parotid gland. Multiple solid masses, most Ͻ1 cm in diameter, were seen within the gland. A retromandibular mass demonstrated cystic necrosis with a rim of peripheral enhancement (Fig 1A). The largest mass, in the tail of the parotid gland, measured 1.6 cm and was suggestive of a metastatic lymph node ( Fig 1B). A more focal well-defined mildly enhancing tumor was also seen within the deep lobe of the parotid gland, measuring 4.2 cm transversely and 2.6 cm anteroposteriorly (Fig 1A, black arrow). The tumor extended from just below the skull base to the angle of the mandible.Total parotidectomy was performed by a combined transparotidsubmandibular approach, sparing the facial nerve. Multiple enlarged well-circumscribed ovoid masses were found in the periparotid region and parotid tail and appeared as lymph nodes. Frozen-se...

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Section: Discussionmentioning

confidence: 99%

Parotid Gland Oncocytosis: CT Findings with Histopathologic Correlation

Shellenberger¹,

Williams²,

Kumar³

2008

AJNR Am J Neuroradiol

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“…Of these, there were only 3 cases of MNOH. Palmer et al 3 proposed the criteria for the classification of oncocytic lesions as oncocytoma, MNOH, diffuse oncocytosis, pleomorphic adenoma with oncocytic change or oncocytic monomorphic adenoma. 3 All of these lesions show the presence of oncocytes, which are characterized by intense eosinophilic granular cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

Multifocal Nodular Oncocytic Hyperplasia in Parotid Gland

et al. 2007

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“…With the exception of papillary cystadenoma lymphomatosum (Warthin tumor), salivary gland tumors with prominent oncocytic features are uncommon, and include oncocytoma, oncocytic carcinoma, and oncocytic cystadenoma, as well as oncocytic variants of pleomorphic adenoma, myoepithelioma, mucoepidermoid carcinoma, and epithelial-myoepithelial carcinoma [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Lau

Thompson

2014

Head and Neck Pathol

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Oncocytic lipoadenoma is an exceedingly uncommon neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Retrospective. Seven cases of oncocytic lipoadenoma were analyzed in order to further characterize the clinical and pathologic features of this rare tumor. The patients included six males and one female who ranged from 40 to 83 years of age (mean 62 years) at presentation. All tumors arose in the parotid gland. Grossly, the tumors were solitary, well circumscribed and had light brown to yellow cut surfaces. Histologically, the tumors were composed of an admixed population of oncocytes and adipocytes in varying proportions, with the lipomatous component ranging from 5 to 70 %. Other common features included the presence of serous acini, ductal elements, sebaceous glands, and a patchy chronic inflammation. Clinical follow up information, available in all cases, with a duration of 3-148 months (mean 57 months), showed no evidence of tumor recurrence. Due to its rarity, oncocytic lipoadenoma can pose problems in diagnosis, although the distinctive morphologic features of this neoplasm allow for separation from more commonly recognized oncocytic neoplasms of the salivary glands.

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Oncocytic adenomas and oncocytic hyperplasia of salivary glands: a clinicopathological study of 26 cases

Cited by 109 publications

References 15 publications

Parotid Gland Oncocytosis: CT Findings with Histopathologic Correlation

Parotid Gland Oncocytosis: CT Findings with Histopathologic Correlation

Multifocal Nodular Oncocytic Hyperplasia in Parotid Gland

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

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