Oncogenic Human Papillomavirus Infection and Genotype
Characterization among Women in Orodara, Western Burkina
Faso

Traoré, Issouf; Zohoncon, Théodora Mahoukèdè; Ndo, O; Djigma, Florencia Wendkuuni; Obiri‐Yeboah, Dorcas; Compaoré, Tegwinde Rebeca; Guigma, Sindimalgdé Patricia; Yonli, Albert Théophane; Traore, Germain; Ouédraogo, Paul; Ouédraogo, Charlemagne; Traoré, Yves; Simporé, Jacques

doi:10.3923/pjbs.2016.306.311

Cited by 14 publications

(19 citation statements)

References 17 publications

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“… [15] , [22] , in the United States [23] and in North Africa [24] . On the other hand, our results corroborate those of some studies that had already shown a low prevalence of HPV 16 in some African countries compared to other HR-HPV genotypes [4] , [5] , [6] , [7] , [8] , [25] . Although HPV 16 appears to be the most prevalent in the world and particularly in cases of cervical cancer, studies in the African subregion have shown the existence of other predominant genotypes.…”

Section: Discussionsupporting

confidence: 91%

“…HPV 59 and 39 were not found. Similar studies on HPV conducted in Burkina Faso and Vietnam using the same amplification kit and the same device showed various and predominant genotypes other than 56 and 66 [5] , [6] , [7] , [18] , [19] , [20] .…”

Section: Discussionsupporting

confidence: 55%

“…In this study, the prevalence of HR-HPV infection is high among women in Tenkodogo. Indeed, the overall prevalence of 34.4% carriage of HR-HPV in these women was close to that of 38.3% in Burkina Faso [5] , 35.0% in England [9] , 33.8% in Costa Rica [10] and 33.2% in Benin [11] . On the other hand, it was lower than those of 75.0% in Ghana [12] , 74.0% in Tanzania [13] and 54.0% in South Africa [14] , 41.5% in Burkina Faso [7] obtained from studies of younger populations with a mean age of less than 30 years while that of our study was 35.5 ± 9.5 years.…”

Section: Discussionmentioning

confidence: 52%

“…(2013) [21] found a high frequency of HPV56 and 66 while these genotypes are not covered by the vaccine. The prevalence of 36.5% of HPV 66 found in our study was higher than that of 9.5% found by Traore and al., (2016b) [5] in a similar study conducted in a population of sexually active women in Banfora.…”

Section: Discussionmentioning

confidence: 81%

“…The nonavalent vaccine detects additional high-risk genotypes (HPV16, 18, 31, 33, 45, 52, and 58). HPV studies in Burkina Faso were limited to two regions (central and the high basins) and had shown diverse predominance of HR-HPVgenotypes in women by region [3] , [4] , [5] , [6] , [7] , [8] . Other genotypes would be more common in the African population, particularly in Burkina Faso [4] , [7] , [8] , hence it is of importance to characterize HR-HPV circulating in order to consider adequate prevention strategies.…”

Section: Introductionmentioning

confidence: 99%

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Oncogenic human papillomavirus infection and genotypes characterization among sexually active women in Tenkodogo at Burkina Faso, West Africa

Ouedraogo

Zohoncon²,

Guigma

et al. 2018

Papillomavirus Research

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ObjectiveThis study was conducted to determine the prevalence and distribution of high-risk human papillomavirus (HR-HPV) genotypes among sexually active women in Tenkodogo, Burkina Faso.MethodsAmong 131 sexually active women attending the Tenkodogo Urban Medical Center, endocervical samples were collected prior to screening for precancerous lesions. After viral DNA extraction, fourteen HR-HPV genotypes were characterized by real-time multiplex PCR in these cervical samples.ResultsThe mean age was 35.5 ± 9.5 years. Of the 131 women, 45 were infected with at least one HR-HPV genotype. The prevalence of HR-HPV infection among these women was 34.4%. Among the 45 oncogenic HPV-infected women, single HR-HPV genotype was found in 55.6% while 44.4% were infected with more than one HR-HPV genotype. The most frequent genotypes were HPV56 (36.5%), HPV66 (36.5%).ConclusionTenkodogo women included in this study had a higher prevalence of HPV 56, HPV 66. A larger study with a more representative sample would therefore be needed to determine predominant oncogenic genotypes in the subregion and especially in cancer cases.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Oncogenic human papillomavirus infection and genotypes characterization among sexually active women in Tenkodogo at Burkina Faso, West Africa

Ouedraogo

Zohoncon²,

Guigma

et al. 2018

Papillomavirus Research

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HPV testing on vaginal/cervical nurse-assisted self-samples versus clinician-taken specimens and the HPV prevalence, in Adama Town, Ethiopia

et al. 2019

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This study aimed to determine the feasibility of vaginal/cervical nurse-assisted self-sampling (NASS) and the agreement between human papilloma virus (HPV) tests on self-samples versus clinician-taken (CT) specimens.Women participated voluntarily for cervical cancer screening at St. Aklesia Memorial Hospital. Eighty-three women provided a total of 166 coupled self-taken and CT specimens collected. Specimens were stored at room temperature for a maximum of 10 months and analyzed using validated the RIATOL qPCR HPV genotyping test, a quantitative polymerase chain reaction (qPCR) high-throughput HPV E6, E7 assay. The average age of the participating women was 32 years. Seventy-three women (87.9%) felt that NASS was easy to use. An overall HPV, high-risk (HR) HPV, and low-risk HPV prevalence was 22.7% (15/66), 18.2% (12/66), and 6.1% (4/66), respectively. The overall HR HPV prevalence was 17.2% (NASS) and 15.5% (CT). The most prevalent HPV type was HPV51; HPV 16 was only detected in 1 woman (CT+NASS) and HPV18 only in 1 woman (CT). The overall measurement agreement between self-taken and CT samples was moderate with a kappa value of 0.576 (P < .001). Lifetime partnered with >2 men were associated with HR HPV positivity (P < .001). There was a strong statistical association between HR HPV positivity and visual inspection with acetic acid- positive (P < .001). The NASS for HPV testing could be seen as an alternative option and might be acceptable to Ethiopian women. The overall HR HPV prevalence was comparable with Sub-Saharan countries in the general population.

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Human papillomavirus type 16 (HPV-16) IgG antibody among women of reproductive age presenting at a healthcare facility in Central Nigeria: a pilot study

Adoga¹,

Reuben²,

Abubakar³

et al. 2021

Pan Afr Med J

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Approximately, 70% of cervical cancer cases worldwide are attributable to HPV-16 and HPV-18, with HPV-associated cancers being the second most common infection-related cancers globally. However, there´s paucity of data about this infective agent in Central Nigeria. In a cross-sectional study, we evaluated the seroprevalence of HPV-16 immunoglobulin G (IgG) and risk determinants among women in Central Nigeria as a first step towards evaluating anti-HPV IgM antibody for active cases and determining incidence. Blood samples were collected between August 2016 and January 2018, from 400 consenting women of childbearing age (15-49 years) who completed structured questionnaires. Samples were analyzed using HPV-16 specific IgG ELISA kits (Cusabio Co. Ltd, Germany). Statistical analysis was performed to determine predictors. Overall, we found that 128 (32.0%) had IgG antibody against HPV-16. Seroprevalence by age was 50.0% (15-19 years), 55.0% (20-24 years), 12.9% (25-29 years), 50.0% (30-34 years), 32.1% (35-39 years), 18.2% (40-44 years) and 19.4% (45-49 years) respectively. Factors associated with infection were age (P=0.0002; 95% CI 5.06-31.51), occupation (P<0.0001; 95% CI 1.4-12.6), number of sex partners (P=0.0037; 95% CI 1.27-49.93), history of genital warts (P=0.0203; 95% CI 1.34-9.55) and education level (P<0.0001; 95% CI 3.89-60.11). In addition, forty six (11.5%) reported having the history of genital warts with 268 (67.0%) and 132 (33.0%) subjects being married and single respectively. Individuals who were either artisans or civil servants were 260 (65.0%), whereas 140 (35.0%) were students. Majority, 324 (81.0%), had either primary, secondary or tertiary education with 76 (19.0%) of the subjects having no formal education. In respect of sexual behaviour, 196 (49.0%) reported having at least two sexual partners, out of which 64 (16.0%) had three or more. These findings provide high serological evidence of exposure to HPV-16 in Central Nigeria with implications for national and regional intervention initiatives.

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Oncogenic Human Papillomavirus Infection and Genotype Characterization among Women in Orodara, Western Burkina Faso

Cited by 14 publications

References 17 publications

Oncogenic human papillomavirus infection and genotypes characterization among sexually active women in Tenkodogo at Burkina Faso, West Africa

Oncogenic human papillomavirus infection and genotypes characterization among sexually active women in Tenkodogo at Burkina Faso, West Africa

HPV testing on vaginal/cervical nurse-assisted self-samples versus clinician-taken specimens and the HPV prevalence, in Adama Town, Ethiopia

Human papillomavirus type 16 (HPV-16) IgG antibody among women of reproductive age presenting at a healthcare facility in Central Nigeria: a pilot study

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