Oncogenic microRNAs as biomarkers of oral tumorigenesis and minimal residual disease

Santhi, W.S.; Prathibha, R.; Charles, Sona; Anurup, K.G.; Reshmi, G.; Ramachandran, Surya; Jissa, V T; Stolzmann, Paul; Pillai, M. Radhakrishna

doi:10.1016/j.oraloncology.2013.01.001

Cited by 36 publications

(30 citation statements)

References 38 publications

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“…In addition, the expression of miR-96-5p allows the detection of minimal residual disease in surgical margins. 42 Our findings also indicate that miR-96-5p is upregulated in OSCC and predicts the insurgence of recurrences, which are frequently related to the presence of tumor cells undetected by histology 9 or to field cancerization effects in the surrounding tissues. 10,11 In order to evaluate the functional aspects of the miRNA prognostic signature, we performed a prediction analysis of their target genes.…”

Section: Discussionsupporting

confidence: 60%

“…Of note, a recent report showed that the expression of miR‐96‐5p is associated with oral tumorigenesis: its expression increases progressively from normal tissue to leukoplakia to tumor. In addition, the expression of miR‐96‐5p allows the detection of minimal residual disease in surgical margins . Our findings also indicate that miR‐96‐5p is upregulated in OSCC and predicts the insurgence of recurrences, which are frequently related to the presence of tumor cells undetected by histology or to field cancerization effects in the surrounding tissues …”

Section: Discussionmentioning

confidence: 51%

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MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma

Ganci¹,

Sacconi²,

Manciocco³

et al. 2015

Head & Neck

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 51%

MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma

Ganci¹,

Sacconi²,

Manciocco³

et al. 2015

Head & Neck

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“…Santhi et al analysed 72 miRs reported to be differentially expressed in OSCC and detected decreased expression of miR-125a, miR-184, and miR-16 and an increased expression of miR-96 in both progressive oral mucosal samples and dysplastic surgical margin samples [60]. Further studies are required to define a broader set of miR profiles within a wider range of surgical specimen samples and to correlate results with patient outcomes.…”

Section: Mirs In Hnscc Surgical Marginsmentioning

confidence: 99%

MicroRNAs in Head and Neck Cancer

John

Lee

et al. 2013

International Journal of Dentistry

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microRNAs (miRs) are small noncoding single-stranded RNAs, about 19–25 nucleotides long. They have been shown to be capable of altering mRNA expression; thus some are oncogenic or tumour suppressive in nature and are regulated by cellular and epigenetic factors. The molecular pathogenic pathway of many cancers has been modified since the discovery of miRs. Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer in the world, has recently been associated with infection by the human papillomavirus (HPV). miR expression profiles are altered in the transition from dysplasia to carcinoma, with some changes being specific to the underlying risk factor. This difference is particularly significant in HPV-positive HNSCC where host miRs are modulated by the virus, creating a different profile to HPV-negative HNSCC. Saliva, as an easily collected proximal biofluid containing numerous miRs, presents an attractive noninvasive diagnostic tool in detecting HNSCC and determining prognosis. Furthermore, miRs may play a role in the analysis of surgical margins for residual tumour extension and in the development of novel miR-based therapeutic targets and agents.

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“…Herein, we applied the platform to coanalyze two specific miRNAs, that is, miR 125a and miR 184 , which are associated with the development of oral squamous cell carcinoma . The coanalysis of the two miRNA targets shows great potential for early clinical diagnosis of oral squamous cell carcinoma.…”

Section: Resultsmentioning

confidence: 99%

“…Herein,w ea pplied the platform to coanalyze two specific miRNAs,t hat is, miR 125a and miR 184,w hich are associated with the developmento fo ral squamousc ell carcinoma. [25] The coanalysis of the two miRNA targetss hows great potentialf or early clinicald iagnosis of oral squamous cell carcinoma. As showni nF igure5,a st he concentration of miR 125a/miR 184 increases,t he Ben-eth/Nap-s fluorescence is intensified with a good linear correlation.…”

Section: Construction Of the Dual-transfer Gate By Unified Signald Efmentioning

confidence: 99%

Versatile and Homogeneous DNA Tetraplex Platform for Constructing Label‐Free Logic Devices: From Design to Application

Yang

Yao

et al. 2019

Chemistry A European J

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The design of DNA‐based logic circuits has become an active research field in DNA nanotechnology and holds great potential in intelligent bioanalysis. To date, although many DNA‐based logic systems have been realized, the implementation of advanced logic functions is still challenging, especially with simple and homogeneous compositions. Herein, by integrating two DNA tetraplex structures (G‐quadruplex and i‐motif), a completely label‐free logic platform with high scalability was established, with which a series of advanced functions were realized, including arithmetic (adders and subtractors) and nonarithmetic ones (majority and dual‐transfer gates). Furthermore, the platform was also applied as an intelligent biosensor to coanalyze two cancer‐related micro‐RNAs with high sensitivities and specificities. Considering the excellent versatility, expandability, and biocompatibility, the platform may promote the development of DNA computing and hold great potential in multiparameter sensing and medical diagnosis.

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Oncogenic microRNAs as biomarkers of oral tumorigenesis and minimal residual disease

Cited by 36 publications

References 38 publications

MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma

MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma

MicroRNAs in Head and Neck Cancer

Versatile and Homogeneous DNA Tetraplex Platform for Constructing Label‐Free Logic Devices: From Design to Application

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