Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation

Ghadjar, Pirus; Rhoon, Gerard C. van

doi:10.3390/cancers14102418

Cited by 3 publications

(1 citation statement)

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“…As a consequence of the Dewhirst et al review, the requirement on the applied thermal dose during clinical hyperthermia has become more realistic and modest in the homogeneity and peak of the temperature, whereas the duration of the clinical treatment has remained between 60 and 90 min depending on whether the heating is superficial or deep. Still, the definitions of the optimal thermal dose, as well as the optimal duration between the two modalities, radiotherapy or chemotherapy, and hyperthermia, are not settled and are the subject of ongoing discussions [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating

Androulakis

Ferrero

Oossanen

et al. 2023

Sensors

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While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment modalities. Additionally, it is speculated that different methods of applying hyperthermia, such as water bath heating or electromagnetic energy, may have an effect on the resulting biological mechanisms involved in cell death or in sensitizing tumor cells to other oncological treatments. In order to further quantify and characterize hyperthermia treatments on a cellular level, in vitro experiments shifted towards the use of 3D cell spheroids. These are in fact considered a more representative model of the cell environment when compared to 2D cell cultures. In order to perform radiofrequency (RF)-induced heating in vitro, we have recently developed a dedicated electromagnetic field applicator. In this study, using this applicator, we designed and validated an experimental setup which can heat 3D cell spheroids in a conical polypropylene vial, thus providing a reliable instrument for investigating hyperthermia effects at the cellular scale.

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Section: Introductionmentioning

confidence: 99%