Oncostatin M, Interleukin-6, Glucometabolic Parameters and Lipid Profile in Hypertensive Patients with Prediabetes and Type 2 Diabetes Mellitus

Ashcheulova, Tetyana; Kochubiei, Oksana; Demydenko, Ganna; Gerasimchuk, Nina; Maliy, Alla

doi:10.1515/rjdnmd-2017-0040

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Increase of the circulating levels of OSM in subjects with coronary artery disease, heart failure, pulmonary arterial hypertension, atrial fibrillation has been demonstrated in a number of experimental and clinical studies (23,(26)(27)(28). It became obvious that the data obtained for the role of OSM in heart function depend on the type of the pathological condition and are often quite contradictory.…”

Section: Discussionmentioning

confidence: 99%

Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction

Гусакова

Суслова²,

Kercheva³

et al. 2022

J Med Biochemistry

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Background: The study of laboratory biomarkers that reflect the development of adverse cardiovascular events in the postinfarction period is of current relevance. The aim of the present study was evaluation of oncostatin M (OSM) concentration changes in the early and late stages of myocardial infarction and evaluation of the possibility of its use in prediction of adverse left ventricular remodeling in patients with myocardial infarction with ST-elevated segment (STEMI). Methods: The study involved 31 patients with STEMI admitted in the first 24 hours after the onset of MI and 30 patients with chronic coronary artery disease as a control group. Echocardiographic study was performed on day 3 and in 6 months after STEMI. The serum levels of biomarkers were evaluated on the day of hospital admission and 6 months after MI using multiplex immunoassay. Results: OSM level increased during the first 24 h after the onset of the disease, with the following decrease in 6 months. OSM concentration at admission had correlated with echocardiography parameters and Nt-porBNP, troponin I, CK-MB levels. Our study has demonstrated association of the increased levels of OSM at the early stages of STEMI with development of the adverse LV remodeling in 6 months after the event. Conclusion: Elevation of OSM levels in the first 24 h after STEMI is associated with the development of the adverse LV remodeling in the long-term post-infarction period.

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Section: Discussionmentioning

confidence: 99%

Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction

Гусакова

Суслова²,

Kercheva³

et al. 2022

J Med Biochemistry

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Multiplex Analysis on the Luminex Platform in Complex Estimation of Cardiovascular Biomarker Dynamics in Patients With Acute Myocardial Infarction

Гусакова

Суслова

Ryabov

et al. 2019

RCLD

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The multimarker approach more accurately reflects the key mechanisms of pathogenesis and biochemical interactions, compared with the use of individual indicators. It is a reason of steadily growing interest in the development and use of various combinations of biomarkers in assessing the prognosis and stratification of cardiovascular risk in patients with a wide range of cardiological profiles. Multiplex analysis technology on the Luminex platform is the best tool for the simultaneous quantitative determination of a complex of different biomarkers in a single. Using the MILLIPLEX® MAP Human Cardiovascular Disease Panel, a multiple-fold increase of FABP, Troponin I, CK-MB, BNP, Nt-proBNP, BNP in the first 24 hours after MI, decreasing in 6 months with a high degree of confidence, was shown. There were no differences in the content of LIGHT between the stages of observation, as well as in comparison with the reference range. The content of LIGHT on the first day of MI showed strong positive associations with markers of damage of myocardium and myocardial stress. On the first day of MI, a significant increase in the content of ESM-1, decreasing in 6 months after MI to the reference values was found. Strong positive associations of ESM-1 with Troponin I and BNP levels were established. A significant increase of proinflammatory cytokine OSM on the first day of MI, decreasing in the late post-infarction period to reference values was shown. Correlation analysis revealed direct relationships of OSM with Troponin I, CK-MB, Nt-proBNP and BNP. The use of the MILLIPLEX® MAP Human Cardiovascular Disease Panel 1 diagnostic multimarker panel allowed for the simultaneous quantitative analysis of 11 biochemical parameters, associated with inflammation, atherogenesis, endothelial dysfunction, ischemia and myocardial necrosis. The results can be used to improve the effectiveness of complex diagnostics in patients with primary myocardial infarction with ST segment elevation.

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Oncostatin M, Interleukin-6, Glucometabolic Parameters and Lipid Profile in Hypertensive Patients with Prediabetes and Type 2 Diabetes Mellitus

Abstract: Background and aims:

Cited by 2 publications

References 12 publications

Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction

Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction

Multiplex Analysis on the Luminex Platform in Complex Estimation of Cardiovascular Biomarker Dynamics in Patients With Acute Myocardial Infarction

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