2000
DOI: 10.1093/molehr/6.8.750
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Oncostatin M is produced during pregnancy by decidual cells and stimulates the release of HCG

Abstract: Oncostatin M (OSM) is a member of the interleukin-6 superfamily and a multifunctional cytokine that effects the growth and differentiation of many different cell types. OSM concentrations in the sera of pregnant women were found to be significantly higher than those of non-pregnant women. Western blot analysis revealed that the OSM protein was present in the decidua and chorionic tissue in each trimester. Throughout pregnancy, the amount of the OSM protein in the decidua was larger than that in the chorionic t… Show more

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Cited by 28 publications
(29 citation statements)
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“…The action of Stat3 during decidualization may be mediated by IL-11. In addition, oncostatin M produced by decidual cells can stimulate the release of human chorionic gonadotropin (hCG) in humans (Ogata et al 2000), while hCG is essential for the luteal rescue during the maternal recognition of pregnancy (Duncan 2000). Therefore, how oncostatin M acts during decidualization remains to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…The action of Stat3 during decidualization may be mediated by IL-11. In addition, oncostatin M produced by decidual cells can stimulate the release of human chorionic gonadotropin (hCG) in humans (Ogata et al 2000), while hCG is essential for the luteal rescue during the maternal recognition of pregnancy (Duncan 2000). Therefore, how oncostatin M acts during decidualization remains to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…4). The role of OsM has not been previously investigated in the mouse uterus, but the in human it is reported to reduce proliferation and induce differentiation in uterine stroma in the secretory phase (Ogata et al 2000, Ohata et al 2001) and has been implicated in tissue remodelling in other systems. It has been shown to upregulate both matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in diverse cell types (Richards et al 1993, Korzus et al 1997, Sanchez et al 2004 as well as tissue plasminogen activator and plasminogen activator inhibitor (Macfelda et al 2002, Spence et al 2002, while in human vascular smooth muscle cells it induces alkaline phosphatase (Shioi et al 2002) and in astocytes Cox-2 (Repovic et al 2003).…”
Section: Stromal Phenotype In the Presence Or Absence Of Lifmentioning
confidence: 99%
“…Little is known about the effects of OSM on pregnancy, although OSM concentrations in the sera of pregnant women were found to be significantly higher than that in the sera of non-pregnant women, throughout the pregnancy period [7,8]. It is possible that OSM may affect the invasion and migration processes of the EVTs through various mechanisms, including its effect on EMT during early pregnancy.…”
Section: Introductionmentioning
confidence: 99%