Oncosuppressor proteins of fragile sites are reduced in cervical cancer

Abstract

FHIT and WWOX are tumor suppressor genes that span the common fragile sites FRA3B and FRA16D, respectively. To analyze possible synergisms among these genes in cervical cancer progression, we considered 159 cervical intraepithelial neoplasias, and 58 invasive squamous cell carcinomas of the uterine cervix. FHIT and WWOX proteins were examined by immunohistochemistry and their expression was inversely correlated with precancerous versus invasive lesions. Statistics among biological markers indicated a strong association between FHIT and WWOX. Protein expression of these two genes was also absent or reduced in cancer cell lines. Thus, WWOX may be considered as a novel important genetic marker in cervical cancer and the association between the altered expression of FHIT and WWOX may be a critical event in the progression of this neoplasia.

Bovine papillomavirus: opening new trends for comparative pathology

“…Interestingly, the number of viral DNA copies has been shown to be significantly higher in more aggressive sarcoids, compared with their slowgrowing counterparts [33]. Over the years, the expression of several cancer markers has been studied in equine sarcoids, such as the tumour suppressor gene fragile histidine triad (FHIT), which was found to be down-regulated [34] as in human cervical cancer [35] although, curiously, not in BPV-associated bovine urinary tumours [36]. Such differences make spontaneous, BPV-induced, animal cancer models particularly useful to study the influence of specific host's genes in the carcinogenic process.…”

PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31

“…Persistent infection with human papillomavirus (HPV) plays a critical role in cervical carcinogenesis. However, HPV infection alone is not sufficient to induce malignant transformation, and additional genetic or epigenetic changes in tumor cells are required 4,5 . The development and progression of cervical squamous cell carcinoma (CSCC) are likely to be associated with the loss of growth suppression, increased cell growth rates, and angiogenesis 6,7 .…”

The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern chinese populations

“…WWOX could also activate the tumor suppressor genes like p53, p73 to induce cell apoptosis [11,14,15], and directly suppress the cancerogenic effect of the oncogenes such as c-jun, erbB4, and MDM2 [16][17][18]. Loss or decreased expression of WWOX protein was found in various tumors, including lung cancer [19][20][21][22][23][24][25][26][27][28]. And WWOX knockout mice show increased lung carcinoma susceptibility [7].…”