A wider spreading and larger scale of exchange of Traditional Chinese Medicine (TCM) along the Belt and Road Initiative (BRI) countries would significantly contribute to the advancement of public health in the world. However, due to the differences in the medical care system and cultural background, the spreading of TCM faces big challenges. Based on the analysis of acceptance of TCM along with BRI countries, it is proposed in this article to optimize bilateral cooperation mechanism, enhance people-to-people communication, and strengthen the innovation of TCM.