One-component nano-metal-organic frameworks with superior multienzyme-mimic activities for 1,4-dihydropyridine metabolism

Reactivity of metal–oxo clusters towards biomolecules: from discrete polyoxometalates to metal–organic frameworks

“…282 PCN(Fe) was shown to be active towards an array of reactions, owing to its oxidase-, peroxidase-, and phosphatase-like activity, including the dephosphorylation of ATP with {Zr 6 O 8 } clusters acting as the active site. 282 However, while ATP dephosphorylation was indeed observed, this study did not yield information on the mechanism or the kinetics of the reaction. 282 A more detailed mechanistic study into the reactivity of MOFs towards nucleotides was presented in the first example of phosphoanhydride bond cleavage by a MOF reported in 2020 by Yang et al, which involved the hydrolysis of ATP to ADP/AMP by UiO-66(Ce) (Table 8).…”

MOF catalysis meets biochemistry: molecular insights from the hydrolytic activity of MOFs towards biomolecules

“…One example is copper, which was featured in an early report of the protease-like activity of the Cu-BTC MOF (HKUST-1). 36 Finally, bimetallic MOF structures combining two metal in the SBU, 41 or in the MOF as a whole, 113,114 may prove interesting to enhance and diversify MOF performance.…”

“…Another example of a bimetallic MOF was FePCN MOF. 114 This MOF contains, beside the typical zirconium oxo clusters nodes, iron porphyrin as the organic linker. FePCN was able to not only hydrolyze the ATP, but also exert oxidase and peroxidase activity towards the substrates 1,4-dihydropyridine and H 2 O 2 .…”

Multi-enzyme mimics – cracking the code of subcellular cascade reactions and their potential biological applications

“…The synthesized Fe porous coordination network (FePCN) displayed triple enzyme-like activity including POD, intrinsic OXD and phosphatase (POP). 155 Since MOFs are not just metal nodes that are working on their own, but the organic linkers present in them also play a critical role in their chemistry and morphology, which raises the question about the role an organic linker has in determining the catalytic properties of a nanozyme. As mentioned before, the organic linker could play a role in the adsorption and binding of the substrates, which is a crucial and the initial determining step that a reaction will occur or not.…”

“…The synthesized Fe porous coordination network (FePCN) displayed triple enzyme-like activity including POD, intrinsic OXD and phosphatase (POP). 155…”