One declarative memory system or two? The relationship between episodic and semantic memory in children with temporal lobe epilepsy.

Abstract

This double dissociation suggests that these 2 memory systems may develop independently in the context of temporal lobe pathology, perhaps related to differential effects of dysfunction in the lateral and mesial temporal lobe structures.

Object naming in epilepsy and epilepsy surgery

“…In studies that grouped children with LTLE and children with RTLE together, children with epilepsy performed significantly lower than age-matched controls [99,102]. Studies that have compared pediatric patients with RLTE with those with LTLE on naming have had small sample sizes, with some studies showing significantly poorer naming in LTLE than in RTLE [102] with others showing similar patterns yet without statistically significant group differences [103,104], and with others showing no laterality effects at all [105].…”

Rethinking cognition and behavior in the new classification for childhood epilepsy: Examples from frontal lobe and temporal lobe epilepsies

“…One described a teenager with bilateral frontal foci who experienced a transitory "frontal lobe syndrome" during the [21] 21 n/r b n/a Cohen [23] n/a 24 11.21 6-16.3 Jambaque et al [24] n/a 28 n/r 7-14 Gonzalez et al [25] n/a 43 12.06 5-16 Nolan et al [26] 25 12.8 n/r 32 12.5 n/r Smith & Lah [27] n/a 66 13.55 5.17-18.17 Rzezak et al [28] n/a 19 14.46 8-16 Hershey et al [29] n/a 28 11.20 7-16 Gascoigne et al [30] n/a 23 12.5 n/r Oitment et al [31] n/a 41 n/r 6-18 Gonzalez et al [32] n/a 44 12.23 6-16 Gascoigne et al [33] n/a 21 12 [40] n/a 36 n/r 7-16 a n/a: no patients within this group included in study. b n/r: data not reported in paper.…”

“…These deficits are apparent on tasks of word learning and recall, memory for details of stories, recognition of faces, recognition and recall of abstract designs, and learning of and memory for spatial locations [23][24][25][26][27][28]. These children are adversely affected by interference over relatively short delay intervals [29].…”

“…Even when the materials are learned through extensive repetition to a criterion that is matched to that of healthy controls, children with TLE show abnormally rapid forgetting, in that their recall after one week is impoverished [30]. TLE has also been associated with deficits in aspects of semantic memory, as evident on measures of mental scanning for semantic clues, object naming, verbal fluency, and word definitions [27,28].…”

Dissociating patterns of anterior and posterior hippocampal activity and connectivity during distinct forms of category fluency

“…Our investigation is based on a large body of work that has indicated that the hippocampus contributes to and facilitates many forms of mental search (Addis & Schacter, 2011;Moscovitch, Cabeza, Winocur, & Nadel, 2016;Olsen, Moses, Riggs, & Ryan, 2012;Schiller, et al, 2015), including search through one's semantic knowledge base (Race, Keane, & Verfaellie, 2013;Ryan, Cox, Hayes, & Nadel, 2008;Sheldon & Moscovitch, 2012;Smith & Lah, 2011;Westmacott, Freedman, Black, Stokes, & Moscovitch, 2004;Westmacott & Moscovitch, 2003). A host of studies have found medial temporal lobe (MTL), and more specifically hippocampal, involvement during category fluency, a task that is often considered to be in the domain of semantic memory (e.g., Catheline, et al, 2015;Pihlajamaki, et al, 2000;Ryan, et al, 2008).…”