One-Flask Conversion of Aldehydes into Nitriles

Synthesis and Spectroscopic Properties of Arene-Substituted Pyrene Derivatives as Model Compounds for Fluorescent Polarity Probes

“…Reaction of 7 with hydroxylamine and subsequent thermally induced dehydration gave benzonitrile 4e in 39% yield. [49] Accompanying amounts of non-dehydrated oxime 8 were removed by column chromatography and identified by NMR spectroscopy and mass spectrometry. The yield of 4e could be increased to 81% by dehydration of 8 to 4e with carbon disulfide in the presence of aqueous sodium hydroxide.…”

Red mud catalyzed one-pot synthesis of nitriles from aldehydes and hydroxylamine hydrochloride under microwave irradiation

“…The latter reaction has also been conducted in the microwave oven. 32 Another reported method for nitrile compound synthesis is the one-pot reaction of aldehydes and hydroxylamine using pyridine, 33 Recently, we have reported that RM catalyzes the Knoevenagel and aldol condensation reactions. 58 The results and importance of one-pot reactions 59 encouraged us to study the one-pot synthesis of nitrile compounds from aldehydes and hydroxylamine hydrochloride using RM.…”

Solvent‐free Synthesis of Nitriles from Aldehydes Catalyzed by KF/Al2O3, Montmorillonite KSF and K10

“…10 Efficient one-pot methods were also developed using hydroxylamine hydrochloride and formic acid, 11 selenium dioxide, 12 pyridine in refluxing toluene, 13 or from nitroethane in the presence of sodium acetate buffer 14 or pyridine hydrochloride. 15 Das 16 has reported microwave assisted rapid conversion of aldehydes into nitriles using silica gel supported NaHSO 4 and NH 4 OAc catalysts.…”