One Health training and research activities in Western Europe

Sikkema, Reina S.; Koopmans, Marion

doi:10.3402/iee.v6.33703

Cited by 49 publications

(44 citation statements)

References 11 publications

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“…As they become prevalent, ESBL producers sometimes cause severe bacteremia 238) and pneumonia 239) even in the community. Therefore, we must take a much close look at the trend of ESBL producers in both the human community and the environment including livestock farming environments from "one health" perspective 176,240,241) .…”

Section: Resultsmentioning

confidence: 99%

ESBL-producing <i>Escherichia coli</i> and Its Rapid Rise among Healthy People

et al. 2017

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Since around the 2000s, Escherichia coli (E. coli) resistant to both oxyimino-cephalosporins and fluoroquinolones has remarkably increased worldwide in clinical settings. The kind of E. coli is also identified in patients suffering from communityonset infectious diseases such as urinary tract infections. Moreover, recoveries of multi-drug resistant E. coli from the feces of healthy people have been increasingly documented in recent years, although the actual state remains uncertain. These E. coli isolates usually produce extended-spectrum β-lactamase (ESBL), as well as acquisition of amino acid substitutions in the quinolone-resistance determining regions (QRDRs) of GyrA and/or ParC, together with plasmid-mediated quinolone resistance determinants such as Qnr, AAC(6')-Ib-cr, and QepA. The actual state of ESBL-producing E. coli in hospitalized patients has been carefully investigated in many countries, while that in healthy people still remains uncertain, although high fecal carriage rates of ESBL producers in healthy people have been reported especially in Asian and South American countries. The issues regarding the ESBL producers have become very complicated and chaotic due to rapid increase of both ESBL variants and plasmids mediating ESBL genes, together with the emergence of various "epidemic strains" or "international clones" of E. coli and Klebsiella pneumoniae harboring transferable-plasmids carrying multiple antimicrobial resistance genes. Thus, the current state of ESBL producers outside hospital settings was overviewed together with the relation among those recovered from livestock, foods, pets, environments and wildlife from the viewpoint of molecular epidemiology. This mini review may contribute to better understanding about ESBL producers among people who are not familiar with the antimicrobial resistance (AMR) threatening rising globally.

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Section: Resultsmentioning

confidence: 99%

ESBL-producing <i>Escherichia coli</i> and Its Rapid Rise among Healthy People

et al. 2017

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“…Adoption of One Health approaches is growing, driven in part by the inherent integration of diverse disciplines and in part through the emergence of financial and resource support for policy and program initiatives, educational programs, and research [17] , [18] , [19] , [20] . However, such growth may be constrained by the preferences of journal editors, boundaries on resources, lack of sustainable government commitment, and a paucity of international educational opportunities [5] , [17] , [18] , [20] , [21] , [22] . As One Health re-emerges as a top priority for those involved in the mitigation of diseases and promotion of wellness, it is important to recognize the challenges faced by those who work collaboratively to integrate the knowledge of multiple disciplines.…”

Section: Discussionmentioning

confidence: 99%

Checklist for One Health Epidemiological Reporting of Evidence (COHERE)

et al. 2017

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One Health is defined as the intersection and integration of knowledge regarding humans, animals, and the environment, yet as the One Health scientific literature expands, there is considerable heterogeneity of approach and quality of reporting in One Health studies. In addition, many researchers who publish such studies do not include or integrate data from all three domains of human, animal, and environmental health. This points to a critical need to unify guidelines for One Health studies. This report details the Checklist for One Health Epidemiological Reporting of Evidence (COHERE) to guide the design and publication format of future One Health studies. COHERE was developed by a core writing team and international expert review group that represents multiple disciplines, including human medicine, veterinary medicine, public health, allied professionals, clinical laboratory science, epidemiology, the social sciences, ecohealth and environmental health. The twin aims of the COHERE standards are to 1) improve the quality of reporting of observational or interventional epidemiological studies that collect and integrate data from humans, animals and/or vectors, and their environments; and 2) promote the concept that One Health studies should integrate knowledge from these three domains. The 19 standards in the COHERE checklist address descriptions of human populations, animal populations, environmental assessment, spatial and temporal relationships of data from the three domains, integration of analyses and interpretation, and inclusion of expertise in the research team from disciplines related to human health, animal health, and environmental health.

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“…AMR is a global issue encompassing human, animal, and the environment. Efforts to tackle AMR dissemination thus require the adoption of a “One-Health” approach that promotes integration of public health and veterinary disease, food, and environmental surveillance ( Sikkema and Koopmans, 2016 ). Culture-dependent techniques are frequently used for AMR surveillance in GNB.…”

Section: Introductionmentioning

confidence: 99%

Integron Digestive Carriage in Human and Cattle: A “One Health” Cultivation-Independent Approach

et al. 2017

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Objectives: Dissemination of antimicrobial resistance (AMR) is a global issue that requires the adoption of a “One-Health” approach promoting integration of human and animal health. Besides culture-dependent techniques frequently used for AMR surveillance, cultivation-independent methods can give additional insights into the diversity and reservoir of AMR genetic determinants. Integrons are molecular markers that can provide overall and reliable estimation of AMR dissemination. In this study, considering the “One-Health” approach, we have analyzed the integron digestive carriage from stools of humans and cattle living in a same area and exposed to different antibiotic selection pressures.Methods: Three collections of human [general population (GP) and intensive care unit patients (ICUs)] and bovine (BOV) stool samples were analyzed. The three main classes of integrons were detected using a multiplex qPCR both from total DNA extracted from stools, and from Gram-negative bacteria obtained by culture after an enrichment step.Results: With the cultivation-independent approach, integron carriage was 43.8, 52.7, and 65.6% for GP, ICU, and BOV respectively, percentages being at least twofold higher to those obtained with the cultivation-dependent approach. Class 1 integrons were the most prevalent; class 2 integrons seemed more associated to cattle than to humans; no class 3 integron was detected. The integron carriage was not significantly different between GP and ICU populations according to the antibiotic consumption, whatever the approach.Conclusion: The cultivation-independent approach constitutes a complementary exploratory method to investigate the integron digestive carriage of humans and bovines, notably within subjects under antibiotic treatment. The high frequency of carriage of integrons in the gut is of clinical significance, integrons being able to easily acquire and exchange resistant genes under antibiotic selective pressure and so leading to the dissemination of resistant bacteria.

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One Health training and research activities in Western Europe

Cited by 49 publications

References 11 publications

ESBL-producing <i>Escherichia coli</i> and Its Rapid Rise among Healthy People

ESBL-producing <i>Escherichia coli</i> and Its Rapid Rise among Healthy People

Checklist for One Health Epidemiological Reporting of Evidence (COHERE)

Integron Digestive Carriage in Human and Cattle: A “One Health” Cultivation-Independent Approach

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