We provide evidence through two loops, that rational letters of polylogarithmic Feynman integrals are captured by the Landau equations, when the latter are recast as a polynomial of the kinematic variables of the integral, known as the principal A-determinant. Focusing on one loop, we further show that all square-root letters may also be obtained, by re-factorizing the principal A-determinant with the help of Jacobi identities. We verify our findings by explicitly constructing canonical differential equations for the one-loop integrals in both odd and even dimensions of loop momenta, also finding agreement with earlier results in the literature for the latter case. We provide a computer implementation of our results for the principal A-determinants, symbol alphabets and canonical differential equations in an accompanying Mathematica file. Finally, we study the question of when a one-loop integral satisfies the Cohen-Macaulay property and show that for almost all choices of kinematics the Cohen-Macaulay property holds. Throughout, in our approach to Feynman integrals, we make extensive use of the Gel’fand, Graev, Kapranov and Zelevinskiĭ theory on what are now commonly called GKZ-hypergeometric systems whose singularities are described by the principal A-determinant.