One-pot and facile synthesis of anti-biofouling polymer-modified gadolinium-based nanoprobes for dual-modal imaging and long-lasting tracking

Abstract

PEGylated gadolinium hydroxycarbonate nanoparticles have been designed and synthesized via a one-pot facile route and successfully applied as high-performance dual-modal contrast agents for X-ray CT and MR imaging.

Design of simvastatin-loaded polymeric microbubbles as targeted ultrasound contrast agents for vascular imaging and drug delivery in the identification of atherosclerotic plaque

“…Polymeric microbubbles (MBs) as ultrasound contrast agents (UCAs) are ideal theranostic agents for improving the resolution and sensitivity of clinical US imaging. [5][6][7] They consist of gaseous bubbles encapsulated within an outer shell, oscillating in an acoustic field, and effectively reflecting the ultrasound signal. Gas-filled UCAs have also attracted researchers to investigate ultrasound-triggered drug release, involving noninvasive imaging of most tissues at low concentrations, and to investigate release of loaded therapeutic drugs with the pressure of an ultrasound wave.…”