One-pot B(C₆F₅)₃ catalyzed cascade synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-ones

5,5’-Indigodisulfonic acid as an efficient catalyst for the synthesis of 2,3-dihydroquinazolinone derivatives

“…1 H NMR (400 MHz, DMSO) δ 8.20 (s, 1H), 7.71 -7.63 (m, 3H), 7.45 (td, J = 7.6, 1.0 Hz, 1H), 7.33 (td, J = 7.7, 1.7 Hz, 1H), 7.29 -7.23 (m, 1H), 6.99 (brs, 1H), 6.76 (d, J = 8.2 Hz, 1H), 6.75 -6.69 (m, 1H), 6.09 (s, 1H). 13 13 C NMR spectra are consistent with the literature [2] .…”

“…NMR spectra were measured on Bruker ARX 400 ( 1 H at 400 MHz, 13 C at 101 MHz) nuclear magnetic resonance spectrometers. 1 H-NMR spectra are reported relative to Me4Si (0.00 ppm) or residual solvent signals (d 6 -DMSO: 2.50 ppm, D2O: 4.79 ppm).…”

“…Data for 1 H-NMR spectra are reported as follows: chemical shift (ppm, s = singlet, brs = broad singlet, d = doublet, t = triplet, q = quartet, dd = doublet of doublets, dt = doublet of triplets, dm = doublet of multiplet, ddd = doublet of doublet of doublets, tdd = triplet of doublet of doublets, m = multiplet), coupling constant (Hz), and integration. Data for 13 C-NMR are reported in terms of chemical shift (ppm) relative to residual solvent peak (CDCl3: 77.00 ppm, d 6 -DMSO: 39.52 ppm). Melting points were determined on RY-1G melting point apparatus and are uncorrected.…”

“…1 H NMR (400 MHz, D2O) δ 7.74 (s, 2H), 7.40 (d, J = 8.3 Hz, 2H), 6.32 (d, J = 8.3 Hz, 2H). 13 C NMR (101 MHz, D2O) δ 190. 23, 154.83, 137.75, 136.05, 123.93, 123.75, 120.34, 115.12.…”

Caffeinium Hydrogen Sulphate Catalysed Green Synthesis of 2,3- Dihydroquinazolin-4(1H)-ones and Their Drug-likeness Studies as Antibacterial Agents

“…Among these, the cyclocondensation of anthranilamide with aryl aldehydes is the most effective and popular method for producing 2,3-dihydroquinazolin-4(1H)-ones. For this purpose various catalysts such as strong Bronsted acids, Lewis acids, metal triflates, ammonium salts [12], IL@MNP [13], tribromide ion supported on boehmite nanoparticles [14], B(C6F5)3 [15], nano-ZrO2-Al2O3 [16], urea/zinc chloride [17], Gr@SO3H [18], Fe3O4@PEG-diaza crown ether@Ni [19], Fe3O4@PEG-Ni [20], ZnO nanomicelle [21], SBA-15@n-Pr-THAM-ZrO [22] and MCM-41-SPM-DMG-Cu(II) [23] have been utilized. Many of these systems have several drawbacks, including poor product yields, long reaction times, difficult reaction conditions, expensive catalysts and hazardous solvents.…”