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A series of pyrrole–2–carboxamide derivatives (4a–j) were synthesized and evaluated for theirantibacterial activity. Among the tested compounds, the most effective were 4a, 4b, 4c, 4d, 4e, 4g and 4h with MIC value in the range of 1.05–12.01 μg/mL against Gram–positive and Gramnegativebacterial strains. Further, the synthesized compounds have been screened for their invitro antifungal activity. In the present study, design and expeditious synthesis of novel 1–(4–chlorobenzyl)–N–(4–methoxybenzyl)–1H–pyrrole–2–carboxamide hybrid molecules as promising antibacterial agents.

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The Front Cover shows a core‐substituted naphthalene diimide with dimethylamine (DDPT) groups which has been used as a reversible acid‐base sensor. The color‐changing tides of the sea represent the acid‐base‐mediated colorimetric changes the DDPT probe exhibits, switching from blue to violet. DDPT could be an efficient alternative to overcome the irreversibility of commonly used pH paper, as it also works when immobilized on paper. More information can be found in the Research Article Vishal G. More et al.