One-Pot Biosynthesis of Reduced Graphene Oxide/Prussian Blue Microcubes Composite and Its Sensitive Detection of Prophylactic Drug Dimetridazole

Abstract

Herein, a robust novel electrochemical sensor for the detection of prophylactic drug Dimetridazole (DMZ) has been developed eco-friendly through the green synthesis of reduced graphene oxide/Prussian blue microcubes (rGO/PB MCs), and the fabrication was economically done by efficient screen-printed carbon electrode (SPCE) modification method. It is critical as DMZ excess level in poultry farm imposes carcinogenic threats. A responsive, reproducible and long-lasting DMZ sensor was established using the material composed of Prussian blue microcubes encapsulated by thin sheets of reduced graphene oxide (rGO/PB MCs). The rGO/PB MCs composite is prepared through a facile hydrothermal approach, and its elemental, structural, electrochemical and catalyzing abilities are examined. The composite is fabricated on the SPCE, and the resulting improved electrode showed outstanding electrocatalytic ability toward DMZ and the reduction peak current are correlated to the DMZ concentrations. It retains the more extensive working range between 0.02 μM and 1360.1μM and the detection limit reaches 3.2 nM. It also possesses appreciable sensitivity of 2.2935 μAμM −1 cm -2 . This technique is efficiently applied to the detection of DMZ in spiked samples of milk and egg.

A simple platform for the electro-catalytic detection of the dimetridazole using an electrochemical sensor fabricated by electro-deposition of Ag on carbon graphite: application: orange juice, tomato juice and tap water

“…This means that the reduction reaction of the NO 2 attractor group of the dimetridazole molecules is controlled by diffusion regime processes. This phenomenon is very similar to that obtained by Murugan Keerthi et al [ 18 ]. This conclusion represents an ideal case for quantitative determination of the antiparasitic drug dimetridazole in real samples.…”

Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

“…Therefore, our approach based on the synthesis of ZnS NPs@ rGO by facile sonochemical method. It is noteworthy to mention that the nanomaterials prepared via ultra-sonication exhibit porous nanostructure and porous structure [31] , [32] . In addition, the preparations of nanomaterials based on sonochemical approach are free from toxic solvents and easy to manipulate [33] , [34] , [35] .…”

Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities

“…polymeric coated nanocarriers [12 , 13] . Carbon based nanomaterials, as carbon nanotubes either alone or decorated with other materials [14 , 15] , graphene oxide [16] , [17] , [18] , fullerenes, carbon quantum dots [19] , have been employed for the detection of drugs in biological samples or their imaging ability. Prussian blue cubes are octahedral metal hexacyanoferrates which have been developed as detection tools due to their conductive and magnetic properties [20 , 21] .…”