One‐Pot Construction of Bis‐Heterocycles through Isocyanide Based Multicomponent Reactions

Abstract

Bis‐heterocycles (BHCs) are hybrid molecules comprising two linked, bound, spacer, or fused heterocyclic skeletons. In recent years, these compounds have attracted increased attention of scientific communities because of their improved potential applications than their discrete units. The emergence of numerous synthetic protocols utilizing Isocyanide as one of the components in multicomponent reactions has unleashed innumerable openings to design and synthesize diverse heterocyclic scaffolds and thus Isocyanide based multicomponent reactions (IMCRs) are leading today's MCR chemistry. To date, there has not been any exclusive review on the construction of BHCs via direct IMCRs or its combination with other reaction sequences in one‐pot. This article presents the first overview of IMCRs such as Ugi, Groebke‐Blackburn‐Bienaymé (GBBR), their sequential combination with other reactions, and new IMCRs established for the one‐pot synthesis of BHCs in the last two decades.

One-pot multicomponent polymerization towards heterocyclic polymers: a mini review

“…Furthermore, IMCRs hold promising prospects for discovering novel BHCs with drug-like and luminescent properties, as well as their utility as building blocks for constructing metal organic frameworks and exploring other innovative applications. 15 In addition, Wang et al review recent advancements in polymerizations involving triple bonds, nitriles, and isonitriles, focusing on in situ reactions for heterocyclic polymer construction, offering promising prospects. 16 Besides that, Stiernet and Debuigne review imine-based multicomponent polymerizations (MCPs) for advanced polymer design.…”

One-Pot Synthesis of 1,3,5-Trisubstitued Pyrazoles via Immobilized Thermomyces lanuginosus Lipase (TLL) on a Metal–Organic Framework

“…It is estimated that almost 5% of the available drugs are produced by this method. 17 Until now, various methods for the synthesis of pyrazole and its derivatives have been reported. By using hydrazonoyl chlorides and cinnamic aldehydes in two steps, derivatives of 1,3,5-trisubstituted pyrazole were synthesized (Figure 2, line 1).…”

“…This synthetic method has been used in various fields, including medicinal, polymer, and agricultural chemistry. It is estimated that almost 5% of the available drugs are produced by this method …”

Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

“…Bis-heterocyclic compounds are hybrid complex structures comprising two heterocyclic frames and are extensively present in medicines and natural products. 1 Accordingly, molecules containing bis-heterocycles have received great attention among the worldwide scientific community due to the enhanced potential applications in comparison with their sole heterocycles. 2 Moreover, novel bis-heterocyclic structures supply unexplored chemical compounds, which may exhibit special biological and pharmaceutical attributes because of the synergistic effects.…”