One-pot controllable synthesis of carboxylic group functionalized hollow mesoporous silica nanospheres for efficient cisplatin delivery

Farsangi, Zohreh Jomeh; Beitollahi, Ali; Hatton, Benjamin D.; Sarkar, Saeed; Jaafari, M. R.; Rezayat, Mehdi; Amani, Amir; Gheybi, Fatemeh

doi:10.1039/c6ra10856c

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…Farsangi et al prepared HMSNP-COOH carriers and loaded cisplatin in them via coordination bonds between carboxylic groups and Pt atoms in cisplatin molecules. 42 These nanomedicines had a pH-dependent release pattern with drug-loading content as high as 48 wt%.…”

Section: Mesoporous Silica-based Materials As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

436

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Mesoporous Silica-based Materials As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

436

268

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“…Comparing the spectrum of NH 2 -Pr-SBA-15 to that of E-NH 2 -Pr-SBA-15 nanobiocomposite, the increase in the intensities of the peaks around 2930 and 600 cm -1 might be attributed to the C-H and N-H stretching vibrations of the lipase enzyme [46]. Besides, the appearance of peaks within 1780 to 1860 cm -1 would be attributed to the C�O of peptide and carboxylic moieties in the lipase enzyme [50]. Te increase in intensities of peaks around 1440 and 1530 cm -1 besides the appearance of the peak around 1640 cm -1 indicates-CH and-NH 2 moieties of the lipase enzyme [21].…”

Section: Te Stability Of the Prepared E-nhmentioning

confidence: 91%

Valorization of Waste Cooking Oil into Biodiesel via Bacillus stratosphericus Lipase Amine-Functionalized Mesoporous SBA-15 Nanobiocatalyst

Ismail

Kashtoh

Betiha

et al. 2022

International Journal of Chemical Engineering

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In this study, evaporation-induced self-assembly was applied to prepare amine-functionalized nano-silica (NH2-Pr-SBA-15). That was simply used to immobilize Bacillus stratosphericus PSP8 lipase (E–NH2–Pr-SBA-15), producing a nanobiocatalyst with good stability under vigorous shaking and a maximum lipase activity of 45 ± 2 U/mL. High-resolution X-ray diffractometer, Fourier transform infrared spectroscopy, N2 adsorption-desorption, field-emission scanning electron, and high-resolution transmission electron microscopic analyses proved the successful SBA-15 functionalization and enzyme immobilization. Response surface methodology based on a 1/2 fraction-three-levels face center composite design was applied to optimize the biodiesel transesterification process. This expressed efficient percentage conversion (97.85%) and biodiesel yield (97.01%) under relatively mild operating conditions: 3.12 : 1 methanol to oil ratio, 3.08 wt.% E–NH2–Pr-SBA-15 loading, 48.6°C, 3.19 h at a mixing rate of 495.53 rpm. E–NH2–Pr-SBA-15 proved to have a long lifetime, operational stability, and reusability.

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“…136 Cisplatin, a chemotherapeutic agent used for various types of cancer, has been employed on a variety of SiO 2 mesoporous supports. [45][46][47] Gu et al demonstrated that COOH-MCM-41 enhanced the adsorption of this drug which exhibited a higher antitumor activity and more accumulation in HeLa cells when compared to free cisplatin. 45 In particular, they followed the uptake of Pt in HeLa cells using ICP-AES as shown in Fig.…”

Section: Drug Deliverymentioning

confidence: 99%

“…46 Jomeh Farsangi et al used double templated mesoporous SiO 2 modified with CES observing slowrelease cisplatin profiles which can be accelerated when lowering the pH of the solution, an interesting feature as cancerous cells have a low pH environment. 47 Delivery is not restricted to medicinal components alone: herbicides such as 2,4-D and picloram have also been evaluated. 186 Given that surface charge of the oxide framework can be easily tuned with the solution pH, Saikia et al devised the selective adsorption of two proteins with different isoelectric points, papain (pI B 8.75) and hemoglobin (pI B 6.8).…”

Section: Drug Deliverymentioning

confidence: 99%