One-pot Mukaiyama–Mannich reaction of aldehydes, amines and silyl enol diazoacetate catalyzed by MgI<sub>2</sub> etherate

In the category of drugs approved by the U.S. FDA, pyrrolidine is the most frequently used core of five-membered nonaromatic heterocycles containing nitrogen. Herein, a Rh(II)/Pd(0) dual-catalyzed carbenoid N-H insertion/allylation cascade reaction has been developed. This protocol provide an efficient approach for the construction of diverse highly functionalized and polysubstituted pyrrolidines in high yields (up to 91%) with excellent chemoselectivities and high diastereoselectivities (>20:1) under mild reaction conditions.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

One-pot Mukaiyama–Mannich reaction of aldehydes, amines and silyl enol diazoacetate catalyzed by MgI₂ etherate

Cited by 2 publications

References 15 publications

Highly efficient Mukaiyama-Mannich addition of α-diazo silyl enolate with nitrones catalyzed by MgI2 etherate

Highly efficient Mukaiyama-Mannich addition of α-diazo silyl enolate with nitrones catalyzed by MgI2 etherate

Rh(II)/Pd(0) Dual Catalysis: Carbenoid N-H Insertion/Allylation Cascade Reaction to Construct Highly Functionalized and Polysubstituted Pyrrolidines

Contact Info

Product

Resources

About

One-pot Mukaiyama–Mannich reaction of aldehydes, amines and silyl enol diazoacetate catalyzed by MgI2 etherate

Cited by 2 publications

References 15 publications

Highly efficient Mukaiyama-Mannich addition of α-diazo silyl enolate with nitrones catalyzed by MgI2 etherate

Highly efficient Mukaiyama-Mannich addition of α-diazo silyl enolate with nitrones catalyzed by MgI2 etherate

Rh(II)/Pd(0) Dual Catalysis: Carbenoid N-H Insertion/Allylation Cascade Reaction to Construct Highly Functionalized and Polysubstituted Pyrrolidines

Contact Info

Product

Resources

About

One-pot Mukaiyama–Mannich reaction of aldehydes, amines and silyl enol diazoacetate catalyzed by MgI₂ etherate