One‐Pot Multicomponent Synthesis of β‐Amino Amides

Abstract

Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity.H erein, an ovel one-pot multicomponent synthesis of b-amino amides from aldehydes, anilines,c arboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability.M oreover,a ni sotope labeling reaction was conducted to elucidate ap lausible reaction mechanism. Scheme 1. Multicomponent reactions for access to amino amides.

A novel and efficient magnetic nanocatalyst functionalized with 1,3,5-tris(2-hydroxyethyl)isocyanurate and boric acid for the synthesis of symmetric and asymmetric Hantzsch esters

“…Multicomponent reactions (MCRs) are one-pot reactions. [1] Several descriptive tags are regularly attached to MCRs: they are atom economic, efficient, convergent and exhibit a very high bond-forming-index (BFI); thus, MCRs are usually a good substitute for sequential multistep synthesis. [2] The product of many multi-component reactions is the heterocyclic compounds.…”

Iridium‐Catalyzed Hydroxyl‐Enabled Cycloaddition of Azides and Alkynes

“…[11] In continuation of our interests in reaction of azides and alkynes, [12] we assumed that a hydroxyl group of internal alkynes might act as directing group to enable cycloaddition with azides. [11] In continuation of our interests in reaction of azides and alkynes, [12] we assumed that a hydroxyl group of internal alkynes might act as directing group to enable cycloaddition with azides.…”

“…The next survey of solvents showed that DCE, THF, toluene, methanol and even water were all effective to afford the product in excellent yield (entries [10][11][12][13][14]. Initially, we set the reaction at room temperature in CH 2 Cl 2 and CuI (2 mol%) was used as catalyst ( fication showed that 3 a was a 1,2,3-triazole, indicating a cycloaddition occurrence.…”

“…Hydroxyl is a fundamental group in organic synthesis, and could serve as directing group in transition metal catalysis. [11] In continuation of our interests in reaction of azides and alkynes, [12] we assumed that a hydroxyl group of internal alkynes might act as directing group to enable cycloaddition with azides. Herein, we would like to report a novel iridiumcatalyzed hydroxyl-enabled cycloaddition of azides and alkynes with high regioselectivity, high efficiency and biocompatible reaction condition (Scheme 1D).…”

“…The screening of catalysts showed that [Rh(cod)Cl] 2 was good (entry 8) while Cp*Ru(cod) was inferior (entry 9). The next survey of solvents showed that DCE, THF, toluene, methanol and even water were all effective to afford the product in excellent yield (entries [10][11][12][13][14]. Notably, this reaction was conducted at room temperature in air.…”