One‐pot synthesis and functionalisation of Fe
 2
 O
 3
 @C‐NH
 2
 nanoparticles for imaging and therapy

Li, Xiaofeng; Ding, Jiabao; Wei, Kai; Weng, Jian; Wang, Jinan

doi:10.1049/iet-nbt.2012.0015

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…The interaction between peptides and the cell membrane is another difference. A healthy cell membrane and peptides make contact through hydrophobic interactions, while electrostatic interactions are involved in the interaction between peptides and the cancer cell membrane [ 32 , 42 ].…”

Section: Cancer Membrane—targeting Receptorsmentioning

confidence: 99%

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Milewska,

Sadowska,

Stefaniuk

et al. 2024

IJMS

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According to data from the World Health Organization (WHO), cancer is considered to be one of the leading causes of death worldwide, and new therapeutic approaches, especially improved novel cancer treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend to have poor pharmacokinetic profiles, including rapid clearance and limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead to remarkable improvements. This is confirmed by an increasing number of papers in this field, showing that the on-target peptide functionalization of magnetic nanoparticles improves their penetration properties and ensures tumor-specific binding, which results in an increased clinical response. This review aims to highlight the potential applications of THPs in combination with magnetic carriers across various fields, including a pharmacoeconomic perspective.

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Section: Cancer Membrane—targeting Receptorsmentioning

confidence: 99%

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Milewska,

Sadowska,

Stefaniuk

et al. 2024

IJMS

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show abstract

“…Interestingly, it has recently been demonstrated that the peroxidase-like activity of Fe 3 O 4 @ carbon NPs can modulate oxidative stress induced by ascorbic acid for the selective killing of PC-3 prostate cancer cells through production of high levels of endogenous ROS [72]. In addition, Li et al have demonstrated that amine-modified group in the surface of core-shell Fe 2 O 3 @ carbon NPs can be functionalized with PEG and FA to enhance their solubility in aqueous solution and target cancer cells [73].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

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Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Zhang

Wang

Gao

et al. 2018

ACS Sustainable Chem. Eng.

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Thus far, tremendous efforts have been made to understand the biosafety of metal-based nanoparticles (MNPs). Nevertheless, most previous studies focused on specific adverse outcomes of MNPs at unrealistically high concentrations with little relevance to the National Institute for Occupational Safety and Health (NIOSH) exposure thresholds, and failed to comprehensively evaluate their toxicity profiles. To address these challenges, we here endeavored to multihierarchically profile the hazard effects of various popularly used MNPs in macrophages under low exposure doses. At these doses, no remarkable cell viability drop and cell death were induced. However, a cellular antioxidant defense system was seen to be initiated in cells by all MNPs even at these low concentrations, albeit to a differential extent and through different pathways, as reflected by differential induction of the antioxidant enzymes and Nrf2 signaling. Regarding inflammation, rare earth oxide nanomaterials (REOs) except nCeO2 greatly increased IL-1β secretion in a NLRP3 inflammasome-dependent manner. By contrast, six REOs, AgNP-5nm, nFe2O3, nFe3O4, and nZnO were found to elevate TNF-α concentration through post-transcriptional regulation. Moreover, all MNPs except nCeO2 drastically altered cellular membrane/cytoskeleton meshwork, but leading to different outcomes, with condensed cellular size and reduced numbers of protrusions by REOs and elongated protrusions by other MNPs. Consequently, REOs (e.g., nDy2O3 and nSm2O3) impaired phagocytosis of macrophages, and other MNPs (such as AgNP-25nm and nZnO) reversely enhanced macrophagic phagocytosis. Alterations of membrane and cytoskeleton meshwork induced by these MNPs also caused disordered membrane potential and calcium ion flux. Collectively, our data profiled the biological effects of different MNPs in macrophages under low exposure doses, and deciphered a complex network that links multiparallel pathways and processes to differential adverse outcomes.

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One‐pot synthesis and functionalisation of Fe ₂ O ₃ @C‐NH ₂ nanoparticles for imaging and therapy

Cited by 3 publications

References 42 publications

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

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One‐pot synthesis and functionalisation of Fe 2 O 3 @C‐NH 2 nanoparticles for imaging and therapy

Cited by 3 publications

References 42 publications

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

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Product

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One‐pot synthesis and functionalisation of Fe ₂ O ₃ @C‐NH ₂ nanoparticles for imaging and therapy