One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid

Convenient Multicomponent One‐Pot Synthesis of 2‐Iminothiazolines and 2‐Aminothiazoles Using Elemental Sulfur Under Aqueous Conditions

“…3). [46] Recently, Kumar et al developed multicomponent method using in situ peroxide-generated aryl iodoalkynes for the ring annulation (Scheme 1, eq. 4).…”

2‐Aminoselenazoles and 2‐aminothiazoles: One‐pot synthesis and control of the fungus Colletotrichum lindemuthianum in common beans

“…On the other hand, to further explore the potential effect of thiazole ring substitution pattern on its antifungal activity against C. lindemuthianum , 2‐aminothiazoles bearing 4‐aryl substituents ( 16 and 17 ) were prepared in a 63–65% yield starting from vinylarenes (styrenes) via co‐halogenation and oxidation of mediated TBCA, followed by a cyclization process (Scheme 3). 51 In this case, TBCA acts as both an electrophilic bromine source and oxidant in a tandem reaction of the vinyl group with excess TBCA. Mechanistically, the reaction proceeds with the regioselective co‐bromination of the styrene with TBCA/H 2 O to produce 2‐bromo‐1‐phenylethanol, 25 which is further oxidized to phenacyl bromide by another equivalent of TBCA.…”

Design of a new method for one-pot synthesis of 2-amino thiazoles using trichloroisocyanuric acid in the presence of a novel multi-functional and magnetically catalytic nanosystem: Ca/4-MePy-IL@ZY-Fe3O4

“…They are also capable of transferring up to three halogen atoms to a substrate, and in reactions involving trihaloisocyanuric acids, the cyanuric acid (CA) by-product can be recycled to make more trihaloisocyanuric acid. 17,18 In a variety of processes, all of these compounds have been demonstrated to be highly effective halenium (X + ) releasing agents, resulting in good to outstanding yields of the appropriate halogenated products under green conditions. Therefore, a variety of products, such as haloarenes, halohydrins, halocarbonyls, etc.…”