One-pot synthesis of 68Ga-doped ultrasmall gold nanoclusters for PET/CT imaging of tumors

Zheng, Benchao; Wu, Qinghe; Jiang, Yifei; Hou, Mengfei; Zhang, Pengli; Liu, Meirong; Zhang, Lu; Li, Biao; Zhang, Chunfu

doi:10.1016/j.msec.2021.112291

Cited by 11 publications

(12 citation statements)

References 79 publications

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“…In these studies, radionuclides in the form of metallic ions or halogen ions are either co-reduced into the lattice of AuNP (e.g. 64 Cu (Frellsen et al 2016 ; Sun et al 2014 ; Pretze et al 2019 ; Zhao et al 2014 ), 111 In (Zheng et al 2021 ) and 68 Ga (Zheng et al 2021 )) or chemically absorbed on the surface of AuNP ( 125 I, 124 I (Lee et al 2016 ; Lee et al 2017 ) and 211 At (Dziawer et al 2017 )). In most cases, the radiolabelling stability and the tumor uptake of the radionuclides appear to be improved after being loaded on AuNPs when compared to the common chelator approaches (Pretze et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Core–shell structured gold nanoparticles as carrier for 166Dy/166Ho in vivo generator

Wang

Ponsard

Wolterbeek

et al. 2022

EJNMMI radiopharm. chem.

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Background Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β− emitters are frequently used in RNT due to the long tissue penetration depth of the β− particles. The dysprosium-166/holmium-166 (166Dy/166Ho) in vivo generator shows great potential for treating large malignancies due to the long half-life time of the mother nuclide 166Dy and the emission of high energy β− from the daughter nuclide 166Ho. However, the internal conversion occurring after β− decay from 166Dy to 166Ho could cause the release of about 72% of 166Ho when 166Dy is bound to conventional chelators. The aim of this study is to develop a nanoparticle based carrier for 166Dy/166Ho in vivo generator such that the loss of the daughter nuclide 166Ho induced by internal conversion is prevented. To achieve this goal, we radiolabelled platinum-gold bimetallic nanoparticles (PtAuNPs) and core–shell structured gold nanoparticles (AuNPs) with 166Dy and studied the retention of both 166Dy and 166Ho under various conditions. Results The 166Dy was co-reduced with gold and platinum precursor to form the 166DyAu@AuNPs and 166DyPtAuNPs. The 166Dy radiolabelling efficiency was determined to be 60% and 70% for the two types of nanoparticles respectively. The retention of 166Dy and 166Ho were tested in MiliQ water or 2.5 mM DTPA for a period of 72 h. In both cases, more than 90% of both 166Dy and 166Ho was retained. The results show that the incorporation of 166Dy in AuNPs can prevent the escape of 166Ho released due to internal conversion. Conclusion We developed a chelator-free radiolabelling method for 166Dy with good radiolabelling efficiency and very high stability and retention of the daughter nuclide 166Ho. The results from this study indicate that to avoid the loss of the daughter radionuclides by internal conversion, carriers composed of electron-rich materials should be used.

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Section: Introductionmentioning

confidence: 99%

Core–shell structured gold nanoparticles as carrier for 166Dy/166Ho in vivo generator

Wang

Ponsard

Wolterbeek

et al. 2022

EJNMMI radiopharm. chem.

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“…All chemicals were purchased from Sigma-Aldrich (Shanghai, China) unless indicated elsewhere. Glutathione-coated AuNCs (GSH@AuNCs) was synthesized according to our previous report with some modifications [ 49 ]. Briefly, 82.3 μL of HAuCl 4 solution (243 mM) was added into glutathione solution (4 mM, 10 mL) under rapidly stirring at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…A series of dilutions of the 89 Zr solutions were measured to obtain a standard calibration curve. Then, the half-lives of different 89 Zr-labeled AuNCs were fitted using a two-compartment intravenous injection model [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor

Jiang

Hou

et al. 2023

Materials Today Bio

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“…The use of radionuclides (e.g., 64 Cu, 68 Ga, 124 I, etc.) to label AuNCs enables PET and PET/CT imaging and improves the sensitivity of detection ( Han et al., 2020a ; Sultan et al., 2021 ; Zheng et al., 2021a ). Modification of AuNCs using Gd ions or Gd complexes also enables MRI ( Liang and Xiao, 2017 ; Liang et al., 2013 ; Sun et al., 2013 ).…”

Section: Justification Of Auncs For Bioimagingmentioning

confidence: 99%

“…(2020a) labeled human serum albumin and luteinizing hormone-releasing hormone-modified AuNCs with 124 I and achieved a 73% labeling rate for targeted identification of tumor tissue in the lungs. Zheng et al. (2021a) prepared two types of 68 Ga-labeled AuNCs, namely GSH-AuNCs ( 68 Ga-GSH@AuNCs) and GSH and arginine-glycine-aspartate tripeptide (RGD) co-modified AuNCs ( 68 Ga-RGD-GSH@AuNCs).…”

Section: Advances Of Auncs Applied In Bioimagingmentioning

confidence: 99%

Advances of gold nanoclusters for bioimaging

Zhang

Gao²,

Chen

et al. 2022

iScience

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One-pot synthesis of 68Ga-doped ultrasmall gold nanoclusters for PET/CT imaging of tumors

Cited by 11 publications

References 79 publications

Core–shell structured gold nanoparticles as carrier for 166Dy/166Ho in vivo generator

Core–shell structured gold nanoparticles as carrier for 166Dy/166Ho in vivo generator

pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor

Advances of gold nanoclusters for bioimaging

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