One-pot synthesis of antibacterial chitosan/silver bio-nanocomposite hydrogel beads as drug delivery systems

Yadollahi, Mehdi; Farhoudian, Sana; Namazi, Hassan

doi:10.1016/j.ijbiomac.2015.04.032

Cited by 223 publications

(69 citation statements)

References 45 publications

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“…In another study, AgNPs were synthesized during in situ formation of physically crosslinked chitosan (CS) hydrogel beads. 42 The formed AgNPs smoothed the surface morphology of the CH/Ag hydrogel beads, while also decreasing the amount of intact drug, which could be loaded onto the beads. Loading of ibuprofen into resulting nanoparticles showed prolonged release of drug with increased amount of AgNPs in the CH/Ag beads, making the beads particularly favorable for controllable drug release applications.…”

Section: Nanoparticlesmentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

531

334

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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Section: Nanoparticlesmentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

531

334

View full text Add to dashboard Cite

show abstract

“…Due to its unique characteristics such as pHsensitivity, transparency, hydrophilicity, non-toxicity, biocompatibility, and biodegradability as well as its gel and film forming properties, CMC has a great potential for use in biomedical applications (Yadollahi et al, 2015b(Yadollahi et al, , 2015c. On the other hand, in the presence of Fe 3+ and Al 3+ , CMC can form spherical gel beads.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl cellulose capsulated layered double hydroxides/drug nanohybrids for Cephalexin oral delivery

Barkhordari

Yadollahi

2016

Applied Clay Science

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“…Antibacterial Cefixime CS/PEG Atta et al [43] Antibacterial and anticancer Polymyxin and paclitaxel Methacrylated mucin Duffy et al [44] Anti-inflammatory Indomethacin TGAP and TGAP-GDE Hosaini et al [45] Antibacterial Escherichia coli and staphylococcus aureus CS-ZnO NPs Yadollahi et al [46] Antibacterial Escherichia coli and staphylococcus aureus CS-Ag NPs Yadollahi et al [47] Anti-inflammatory Diclofenac sodium CMC-AgNPs Gulsonbi et al [48] Respiratory activity Theophylliine CNC-Gt Ooi et al [49] Anti-inflammatory Indomethacin PLGA-NH 2 -Gt Chung et al [50] Anti-inflammatory and anticancer 5-Fluorouracil and diclofenac CMCS-PNIPA m -GMA Zhang et al [51] Anti-inflammatory Aspirin CD-g-CMCs Kono et al [52] tissue. These hydrogels are retained and released linearly both paclitaxel and polymyxin B drugs with time over seven days.…”

Section: Biomedical Application Model Drug Used Types Of Hydrogels Rementioning

confidence: 99%

“…The content of ZnONPs was increased in the hydrogels, the potential of controlled drug release also increased. Yadollahi et al [51] were also prepared chitosan-silver nanocomposite hydrogels via in situ formation of AgNPs in the chitosan hydrogel environment with sodium tripolyphosphate as a cross linker.…”

Section: Biomedical Application Model Drug Used Types Of Hydrogels Rementioning

confidence: 99%

Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

Gopi¹,

Amalraj²,

Thomas³

2016

Drug Des

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Design and synthesis of well-ordered drug delivery systems are very important for medicinal and pharmaceutical and health care. Innovations of materials through nanotechnology and hydrogels have synergistically energized the growth of drug delivery. Uniqueness in material chemistry permits the creation of environmentally approachable, biocompatible, biodegradable and targeted drug delivery system. Large numbers of biopolymers have been examined for the design of drug delivery systems. Structure, size, shape and multi-functionality of drug delivery system can be controlled by the nanotechnology combined with biopolymer. Hydrogels have also been investigated as smart delivery systems capable to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. This review mainly focuses on drug delivery applications of nanoparticles modified biopolymers and effective drug delivery system of biopolymer network based on hydrogels.

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One-pot synthesis of antibacterial chitosan/silver bio-nanocomposite hydrogel beads as drug delivery systems

Cited by 223 publications

References 45 publications

Antibacterial properties and toxicity from metallic nanomaterials

Antibacterial properties and toxicity from metallic nanomaterials

Carboxymethyl cellulose capsulated layered double hydroxides/drug nanohybrids for Cephalexin oral delivery

Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

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