One Pot Synthesis of CuO-CuFe₂O₄@rGO Nanostructure with Synergistic Effect for Efficient Electrochemical Sensing Application of Paracetamol

Abstract

In the present study, the facile and synergistic approach for electrochemical sensing of paracetamol (PA) drug was demonstrated by hydrothermally synthesized copper oxide-copper ferrite nanohybrid composite supported on reduced graphene oxide (CuO-CuFe2O4@rGO) glassy carbon electrode. The surface texture and structural information of the electrode material were examined by FE-SEM, HR-TEM, and X-ray diffraction techniques, whereas the electrochemical sensing application of paracetamol oxidation was investigated by cyclic voltametry method. The average crystallite size of CuO-CuFe2O4 was calculated from XRD data and found to be 35.45 nm. The fabricated sensor exhibited a higher sensitivity of 970.26 µA.mM-1.cm-2along with a lower limit of detection (LOD) and limit of quantification (LOQ) of 7.0 µM and 25 µM, respectively, with a linear dynamic range of 10 - 1200 µM. Furthermore, the CuO-CuFe2O4@rGO modified sensor showed excellent anti-interferents ability, long-term stability and reproducibility towards electro-oxidation of paracetamol drug. Moreover, it can be efficiently applied for the analysis of paracetamol in biological samples. Finally, the synthesized nanocomposite material was validated to be a competent electro-catalyst for electrochemical sensing application of paracetamol.

Layered Yttrium Oxide Reinforced Graphene Oxide Electrode Surface for Voltammetric Determination of Paracetamol

“…also used NaCl, KCl, glucose, uric acid, ascorbic acid, and dopamine as the species that can interfere with the PCM analyte and tested them by the amperometric method. According to the data they obtained, it was stated that the species with the potential to interfere show a negligible peak current value [48]. Thus, it has been determined that the studies conducted for GO@YO/GCE are compatible with the literature.…”

CuFe2O4 Nanofiber Incorporated with a Three-Dimensional Graphene Sheet Composite Electrode for Supercapacitor and Electrochemical Sensor Application

“…W. Liang et al fabricated CuFe 2 O 4 for electrical energy storage [46]. J. C. Bhangoji et al identified CuO-CuFe 2 O 4 @rGO for paracetamol sensing [47]. V. Mahdikhah [49].…”