In the present study, the facile and synergistic approach for electrochemical sensing of paracetamol (PA) drug was demonstrated by hydrothermally synthesized copper oxide-copper ferrite nanohybrid composite supported on reduced graphene oxide (CuO-CuFe2O4@rGO) glassy carbon electrode. The surface texture and structural information of the electrode material were examined by FE-SEM, HR-TEM, and X-ray diffraction techniques, whereas the electrochemical sensing application of paracetamol oxidation was investigated by cyclic voltametry method. The average crystallite size of CuO-CuFe2O4 was calculated from XRD data and found to be 35.45 nm. The fabricated sensor exhibited a higher sensitivity of 970.26 µA.mM-1.cm-2along with a lower limit of detection (LOD) and limit of quantification (LOQ) of 7.0 µM and 25 µM, respectively, with a linear dynamic range of 10 - 1200 µM. Furthermore, the CuO-CuFe2O4@rGO modified sensor showed excellent anti-interferents ability, long-term stability and reproducibility towards electro-oxidation of paracetamol drug. Moreover, it can be efficiently applied for the analysis of paracetamol in biological samples. Finally, the synthesized nanocomposite material was validated to be a competent electro-catalyst for electrochemical sensing application of paracetamol.

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A simple and environment friendly protocol has been developed for the synthesis of Ag nanoparticles (AgNPs) supported on reduced graphene oxide (rGO) with copper metal foil as reductant. The prepared AgNPs-rGO, nanocomposite was characterized by various analytical techniques such as scanning electron microscopy (SEM), field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD). The electrochemical performance of the material has been evaluated using cyclic voltammetry (CV), chronoamperometry and electrochemical impedance spectroscopy (EIS). The average crystallite size of AgNPs is found to be 32.34 nm. The application of prepared electrocatalyst (AgNPs-rGO) as a non-enzymatic sensor is examined through the modified electrode with the synthesized AgNPs-rGO. The sensor showed excellent performance toward H2O2 reduction with a sensitivity of 12.73 µA.cm-2.mM-1, with a linear dynamic range of 1.5 µM – 100 mM, and the detection limit of 1.90 µM (S/N = 3). Furthermore, the sensor displayed high sensitivity, reproducibility, stability and selectivity for the determination of H2O2. The results demonstrated that AgNPs-rGO has potential applications as sensing material for quantitative determination of H2O2.

A simple and environmentally‐friendly approach was developed to synthesize 2D CuO nanosheets using electrochemical deposition. The formed 2D CuO nanosheets (NSs) exhibit numerous advantageous properties such as no toxicity, high electrical conductivity, large active surface area, and a p‐type semiconducting nature with a band gap of 1.2 eV. A sensitive electrochemical sensor was constructed for the amperometric detection of glucose to take advantage of these characteristics. The fabricated sensor displayed an excellent sensitivity of 2710 μA mM−1 cm−2 along with a wide linear range of 0.001–1.0 mM and a lower limit of detection of 0.8 μM (S/N=3). Additionally, the modified electrode possesses high selectivity and good stability. The outstanding electrocatalytic performance of the electrode is attributed to a large active surface area, unique structural morphology, and the high conductivity of the 2D CuO nanosheets.