One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

Meng, Lingjie; Xu, Chunguang; Liu, Tianhui; Li, Hua; Lu, Qinghua; Jiang, Long

doi:10.1039/c5py00196j

Cited by 49 publications

(29 citation statements)

References 40 publications

(71 reference statements)

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“…Highly crosslinked polyphosphazene nano/micro materials, a kind of novel versatile hybrid material referring to polymers synthesized via polycondensation between hexachlorotriphosphazene (HCCP) and polyamino (or polyhydroxyl) monomers, have been designed for use in cell imaging, drug delivery, sensing, and ecological environment . The polyphosphazenes have special characteristics including highly crosslinked structure, water and organic media dispersibility, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Chen

Liu

et al. 2020

J of Applied Polymer Sci

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Amino-functionalized highly crosslinked organic-inorganic hybrid polyphosphazene microspheres were prepared via a one-pot polycondensation method and served as a fluorescent sensor for the detection of Fe 3+ in solution. With the introduction of p-phenylenediamine unites, the polyphosphazene microspheres could be endowed with fluorescent property and abundant active amino groups on the surface. The microspheres were further used as the fluorescent sensor for the detection of Fe 3+ . Fluorescence study showed high sensing sensitivity and selectivity of the microspheres, and the limit of detection was determined as 0.076 μM for Fe 3+ . Active amino groups on the surface could efficiently improve the detection sensitivity of Fe 3+ . Moreover, highly crosslinked organic-inorganic hybrid structure was beneficial to the photostability and thermostability, enabled the microspheres to be possible for constructing practicable sensors. This work is expected to inspire the design of advanced polyphosphazene-based fluorescent sensors for applications in analytical detection.

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Section: Introductionmentioning

confidence: 99%

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Chen

Liu

et al. 2020

J of Applied Polymer Sci

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“…FI techniques have the advantage of having high spatial and time resolution and have gained much attention in the field of biomedicine. Inspired by the aggregation-induced emission (AIE) mechanism proposed by Tang et al, 128 Long et al 129 introduced polyphosphazene (PZS) to ''isolate'' and ''fasten'' the fluorescent molecules for a stable and enhanced FI performance. The fluorescent molecules were bound to the phosphorus-containing dendrimer.…”

Section: Theranosticsmentioning

confidence: 99%

Phosphorus Science-Oriented Design and Synthesis of Multifunctional Nanomaterials for Biomedical Applications

Tang

Kong

Ouyang

et al. 2020

Matter

177

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Phosphorus plays an indispensable role in energy metabolism, acid-base balance, and genetic substances transfer. As nanotechnology advances, plenty of phosphorus-based nanomaterials have been developed and widely used in the fields of biology and medicine. The size and structure of phosphorus-based nanomaterials give them unique physicochemical, optical, and biological properties, greatly increasing the variety of nanomedicine. The excellent properties further promote the applications of phosphorus-based nanomaterials in drug nanocarriers, tumor theranostics, biosensors, and bone formation. In this review, we first introduce the phosphorus science to unify current phosphorus-based nanomaterials and discuss their synthesis methods. Furthermore, the representative nanoplatforms utilizing the corresponding properties are highlighted. Finally, research development, potential challenges, and perspectives for further improvement of phosphorus-based nanomaterials in biomedicines are presented.

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“…For vaccine delivery, the most common prototypes are based on PPZs with carboxylic acids side chains, such as poly[di(carboxylatophenoxy)‐phosphazene] (PCPP). The versatility of PPZ chemistry is also important from scale‐up and manufacturer's perspectives . For many industrial applications, it is desirable to have “platform” materials that can be manufactured in bulk and adapted or modified for specific purposes.…”

Section: Part I Background and Fundamental Properties Of Ppzmentioning

confidence: 99%

Polyphosphazenes for the delivery of biopharmaceuticals

Hsu

Csaba

Alexander

et al. 2019

J of Applied Polymer Sci

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Polyphosphazenes (PPZs) are a relatively new family of polymers based on a nitrogen–phosphorous backbone where organic side groups can be grafted. The synthetic route to PPZs is highly versatile such that it is possible to add many different functionalities that change completely the physicochemical and biological properties of the polymers. For instance, PPZs can be designed with a variety of organic side groups that render these materials biodegradable and highly biocompatible. Based on these positive features, PPZs have been explored for many biomedical applications including the design of numerous advanced drug delivery systems. In this area, PPZs have been particularly investigated as materials for the formulation of biopharmaceuticals of high added value. These include protein‐ and polynucleotide‐based medicines, applications where PPZ carriers have obtained very positive results in preclinical models. A further area of major interest for PPZs has been vaccination, where these materials have obtained excellent results in vivo as polymer adjuvants and have advanced to clinical evaluation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48688.

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One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

Cited by 49 publications

References 40 publications

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Phosphorus Science-Oriented Design and Synthesis of Multifunctional Nanomaterials for Biomedical Applications

Polyphosphazenes for the delivery of biopharmaceuticals

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One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

Cited by 49 publications

References 40 publications

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe3+

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe3+

Phosphorus Science-Oriented Design and Synthesis of Multifunctional Nanomaterials for Biomedical Applications

Polyphosphazenes for the delivery of biopharmaceuticals

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Product

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Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺