One‐Pot Synthesis of Highly Fluorescent Poly(methacrylic acid)‐Capped Silver Nanoclusters for the Specific Detection of Iron(II)

Abstract

This work presented an easy synthesis method for water‐soluble, green and fluorescent silver nanoclusters with poly (methacrylic acid) (AgNCs@PMAA) and preliminarily explored their ability to detect Fe2+ by measuring their fluorescence quenching. The acquired AgNCs@PMAA showed steady, selective, and highly sensitive detection of Fe2+. The Fe2+ detection limit for AgNCs@PMAA was 3 μM, and a linear relationship was observed at 5–150 μΜ ion concentration. AgNCs@PMAA had no biological toxicity and could be used for in vivo imaging and detection of iron ions. This fluorescence detection method based on novel nanomaterials exhibits future application in biolabeling, biosensing, and other purposes.

Dual-emission copper nanoclusters–based ratiometric fluorescent probe for intracellular detection of hydroxyl and superoxide anion species

“…Cyan-emissive CuNCs (PCuNCs) were prepared by a simple approach using PMAA as a capping agent and ascorbic acid as a moderate reducing agent. PMAA, a common polyelectrolyte, as a template contains several -COOH groups capable of coordinating with Cu 2+ ions, while the presence of methyl groups in the side chain facilitates the stabilization and formation of metal nanoclusters [42,43]. The orange-emitting CuNCs (BCuNCs) were synthesized at room temperature using a hydrazine hydrate as a reducing reagent and BSA protein as a template for the construction of nanoclusters [41].…”

“…The ideal probe should have high sensitivity for selectively detecting the target analyte [37,40,42]. With due consideration, the fluorescence responses of PCuNCs-BCuNCs towards ROS were monitored in solution under physiological conditions.…”

Poly(methacrylic acid)‐Stabilized Silver Nanoclusters as Colorimetric Sensors for the Rapid and Sensitive Detection of Ascorbic Acid

“…[25,26] Remarkably, the use of scaffolds helps to prevent particle aggregation during nanocluster synthesis. Notably, most of these studies have reported the use of AgNCs as fluorescent probes for the detection of a wide range of analytes, such as metal ions [27] and organic compounds [28,29] with approaches relying on measuring fluorescence quenching.…”