One-pot synthesis of novel pyrimido[4,5-b]quinolines and pyrido[2,3-d:6,5d′]dipyrimidines using encapsulated- γ-Fe2O3 nanoparticles

Abstract

Novel pyrimido[4,5-b]quinolines and pyrido[2,3-d:6,5-d ′ ]dipyrimidine derivatives were synthesized in one-pot, three-component approach using sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe 2 O 3 [γ-Fe 2 O 3 @HAp-SO 3 H] as magnetically recoverable nanocatalyst. The protocol provided a rapid, useful and green method for the preparation of the products in short reaction times and high yields.

Recent advances in the iron‐catalysed multicomponent reactions

“…An eco‐friendly strategy for the synthesis of pyrimido[4,5‐ b ]quinolines 111 was put forward by multicomponent reaction of 6‐amino‐2‐ethylthiopyrimidin‐4(3 H )‐one 110 , dimedone 48 and arylaldehyde 30 using [γ‐Fe 2 O 3 @HAp‐SO 3 H] catalyst in ethanol at 60 °C for 4 min (Scheme 39). [ 69 ] Electron‐donating and electron‐deficient substituted aldehydes reacted well affording the products in excellent yields. Recovery and recycling of catalyst were easy due to its magnetic property.…”

Recent Developments in the MCRs Synthesis of Pyridopyrimidines and Spiro‐Pyridopyrimidines

“…This efficient magnetically reusable catalyst was also used to prepare a series of pyrido[2,3‐ d :6,5‐ d ']dipyrimidines 60 (Scheme ). In this study , butylthiopyrimidin‐4(3 H) ‐one and arylaldehyde in presence of [ γ ‐Fe 2 O 3 @HAp‐SO 3 H] produced desired products. This reaction was also carried out under ultrasonic irradiation without [ γ ‐Fe 2 O 3 @HAp‐SO 3 H] and the result compared with the result in the presence of [ γ ‐Fe 2 O 3 @HAp‐SO 3 H].…”

An expeditious one-pot synthesis of pyrido[2,3-d]pyrimidines using Fe3O4–ZnO–NH2–PW12O40 nanocatalyst

“…According to the results, using 20 mg Fe 3 O 4 -ZnO-NH 2 -PW 12 O 40 in H 2 O at 80 °C proved to be the best condition for this reaction (Table 1). By performing the reaction in the presence of an acid, a base, and a salt, no improvement was achieved (entries [15][16][17]. In order to show the role of catalyst, similar reaction was performed in the absence of the catalyst.…”