One-Pot Synthesis of Phthalazinyl-2-Carbonitrile Indole Derivatives via [Bmim][oh] as Ionic Liquid and Their Anti Cancer Evaluation and Molecular Modeling Studies

Insight into Indole‐Based Heterocyclic Scaffolds: A Medicinal Chemistry Perspective

“…Sindhu Hasthavaram et al [54] reported a method to synthesize indole-carbonitrile derivatives 224 (a-h). Phthalic acid Heba A. H. Elshemy et al [55] developed a protocol for synthesis of pyridyl-indole 227 (a-e Active compounds were also subjected to molecular docking analysis with quadruple mutant Pf DHFR-TS and it was observed that compounds 228 a and 228 k shows strong protein-ligand binding with active site of amino acids which is responsible for their antimalarial activity.…”

“…Sindhu Hasthavaram et al [54] . reported a method to synthesize indole‐carbonitrile derivatives 224 (a–h) .…”