One‐pot synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines using CoFe2O4@SiO2‐PA‐CC‐guanidine‐SA magnetic nanoparticles in water

Rostami, Hedieh; Shiri, Lotfi

doi:10.1002/aoc.6293

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Rostami et al [ 76 ] developed the usage of CoFe 2 O 4 @SiO 2 -PA-CC-guanidine-SA as an adept nanocatalyst for the synthesis of pyridodipyrimidines 41 (Scheme 19 ). Consequently, one-pot multicomponent reactions of aryl aldehyde, barbituric/thiobarbituric acids, and NH 4 OAc produced the expected products in brilliant yields (86–95%).…”

Section: Synthetic Approachesmentioning

confidence: 99%

Developments of pyridodipyrimidine heterocycles and their biological activities

et al. 2023

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The entitled review aimed to assemble and highlight the synthetic approaches and biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic approaches were categorized according to the accomplishments of the approaches under catalyst or catalyst-free conditions. The topic involved the synthesis of substituted tricyclic systems and spirocyclic systems. The present study offered an overview of the recent literature in addition to a scope of the preceding literature. The proposed mechanisms of the varied target products were discussed. Pyridodipyrimidine displayed potential and privileged cytotoxic, antioxidant, and antimicrobial performances. The competitions, challenges, and prospects are also deliberated.

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Section: Synthetic Approachesmentioning

confidence: 99%

Developments of pyridodipyrimidine heterocycles and their biological activities

et al. 2023

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Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

Safari,

Poursattar Marjani,

Sadrmohammadi

2023

Applied Organom Chemis

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Heterocycles and barbituric acid analogs are particularly used in developing and designing new drugs because of their versatile binding properties for different biotargets. They are present in many natural compounds, vitamins, drugs, and biologically active molecules such as anticancer, antibiotic, antidiabetic, anti‐inflammatory, antidepressant, anti‐HIV, antimicrobial, and insecticidal agents. Using co‐friendly techniques under nanocatalyst conditions drives the synthesis of these bioactive compounds toward green chemistry. This review will investigate the nanocatalysts, including magnetic nanocatalysts, nano metal‐based catalysts, organo‐nanocatalysts, and metal–organic frameworks (MOFs) nanocatalysts employed in the synthesis and design of heterocyclic compounds by barbituric acids from 2017 to 2022.

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Synthesis, Molecular Docking and Anticancer Activity of Some 5‐Aryl‐5,10‐dihydropyrido[2,3‐d:6,5‐d′]dipyrimidine‐2,4,6,8‐tetraone Derivatives and Pyrido[2,3‐d]pyrimidines

et al. 2022

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A novel and efficient route towards the synthesis of pyrido [2,3d:6,5-d']dipyrimidines 4 a-g as unexpected products through the reaction of 6-aminouracil (1) and arylidenemalononitrile or ethyl arylidenecyanoacetate in acetic acid were investigated. On the other hand, reaction of 6-aminouracil and ethyl 4nitrobenzylidenecyanoacetate in ethanol in presence of piperidine (few drops) afforded pyrido[2,3-d]pyrimidine-6-carbonitrile 5. In addition, pyrido[2,3-d]pyrimidines 6 a-g were obtained through the reaction of 5 with different aliphatic amines in ethanol in presence of triethylamine (few drops). All reactions proceeded in good to excellent yields and the resulting compounds were characterized by different spectroscopic techniques. The antiproliferative activity of these compounds was evaluated towards HEPG-2, MCF-7 and HCT-116 cell lines. The compound 6 a displayed the highest activity against the tested cell lines, followed by compound 6 d, 6 g and 6 b, with strong affinity to bind with the active and allosteric sites of topoisomerase II, as authenticated from the molecular docking analyses.

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One‐pot synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines using CoFe₂O₄@SiO₂‐PA‐CC‐guanidine‐SA magnetic nanoparticles in water

Cited by 5 publications

References 33 publications

Developments of pyridodipyrimidine heterocycles and their biological activities

Developments of pyridodipyrimidine heterocycles and their biological activities

Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

Synthesis, Molecular Docking and Anticancer Activity of Some 5‐Aryl‐5,10‐dihydropyrido[2,3‐d:6,5‐d′]dipyrimidine‐2,4,6,8‐tetraone Derivatives and Pyrido[2,3‐d]pyrimidines

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