One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium tuberculosis

Zhu, Ping; Cai, Ling; Li, Qiao; Feng, Shanwu; Ruan, Hongjie; Zhang, Li; Zhou, Liuzhu; Jiang, Huijun; Wang, Hongsheng; Wang, Jianming; Chen, Jin

doi:10.1016/j.ejps.2022.106261

Cited by 10 publications

(6 citation statements)

References 51 publications

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“…The interaction between quercetin and PCL nanoparticles occurred due to the characteristic stretching of −CO of quercetin at 1665 cm –1 , but the phenolic OH of quercetin was seen around 3732 cm –1 spectra due to the overlapping of the −CO stretching of PCL at 1730 cm –1 for the Cu-Q-PCL-NPs. The quercetin in the Cu-Q-PCL-NPs is stable according to the spectrum analyses …”

Section: Resultsmentioning

confidence: 99%

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Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

et al. 2022

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The study aimed to improve the treatment of impetigo with naturally occurring quercetin and its copper–quercetin (Cu–Q) complex by preparing sustained-release (SR) nanoparticles of polycaprolactone (PCL). The solvent evaporation method was used for the copper–quercetin (Cu–Q) complex formation, and their PCL nanoparticles (PCL-NPs, Q-PCL-NPs, and Cu-Q-PCL-NPs) were prepared by the high-pressure homogenization method. Synthesis of nanoparticles was confirmed by their physicochemical and antibacterial properties of quercetin against Gram-positive as well as Gram-negative bacteria. The percentage loading efficiency of quercetin and release in 100 mM of phosphate buffer pH 7.4 and 5.5 at 37 °C was found to be more than 90% after 24 h with the zero-order release pattern. Minimum inhibitory concentration of nanoparticles was found to increase threefold in the case of Cu-Q-PCL-NPs may be due to the synergistic antibacterial behavior. Scanning electron microscopy showed spherical nanoparticles, and surface roughness was confirmed by atomic force microscopy analysis. Fortunately, no sign of irritation on rat skin even at 3%, was seen. In vitro antioxidant assay by 2,2-diphenyl-1-picrylhydrazyl reduction was found to be ≤80 ± 0.02% which confirmed their scavenging activity. Interestingly, for the ex vivo study, the tape-stripping model was applied against Staphylococcus aureus containing rats and showed the formation of the epidermal layer within 4–5 days. Confirmation of antibacterial activity of pure quercetin, from Cu–Q complex, and their SR release from Q-PCL-NPs and Cu-Q-PCL-NPs was considered an effective tool for the treatment of skin diseases and can be used as an alternative of already resistant ciprofloxacin in impetigo.

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Section: Resultsmentioning

confidence: 99%

“…The quercetin in the Cu-Q-PCL-NPs is stable according to the spectrum analyses. 30 3.1.2. Thermogravimetric Analysis.…”

Section: Physicochemical Evaluationmentioning

confidence: 99%

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

et al. 2022

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“…The beaker was put on a magnetic stirrer and the temperature was maintained at 37 °C. A magnetic bead stirrer controlled the agitation of the beaker, and aluminum foil was used to protect the beaker to prevent solvent loss throughout the experiment [37,38].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Rodriques¹,

Prajapati²

2022

Pharmacophore

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The purpose of this research was to develop and evaluate the Nanoemulsion of Dolutegravir sodium. Nanoemulsion was made by the high-shear homogenization method. Materials and method: Oleic acid was used as the oil phase, Tween 80, and Acconon MC8-2 EP/NF (Smix; 1:1) were utilized as surfactant and co-surfactant respectively while distilled water was employed as an aqueous phase. The formulations were evaluated based on globule size, zeta potential, pH, viscosity, percentage transmittance, centrifugation, dye test, dilutability test, and Fourier transform spectroscopy. Furthermore, in vitro drug release studies and stability studies were also conducted. NE1 has shown the least particle size of 96.71 nm, viscosity of 86.4 cp, and maximum drug release of 97.55 % CDR in 45 hrs compared with pure drug (32.98% CDR in 45 hrs). The stability study confirmed no changes in formulations at 1 month at 40 0 ± 2 0 C and 75% ± 5%. The findings suggest that nanoemulsions might be an effective vehicle for the oral administration of Dolutegravir sodium for the treatment of HIV.

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“…Since the discovery of penicillin in 1928, antimicrobial drugs have saved many humans from infectious diseases. − Although antimicrobial drugs have contributed enormously to human health, the discovery of novel antimicrobial agents has decreased. , Pharmaceutical companies have withdrawn from developing new antimicrobials because of the repeated emergence of drug-resistant bacteria and the limited duration of approved treatment, leading to a low profit-to-development cost ratio. Therefore, there is an emerging trend that conventional drugs approved for a specific disease are used to treat other diseases, requiring no regulatory approval . This concept is called “drug repositioning”, , which has been used to treat coronavirus infections …”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there is an emerging trend that conventional drugs approved for a specific disease are used to treat other diseases, requiring no regulatory approval. 6 This concept is called "drug repositioning", 7,8 which has been used to treat coronavirus infections. 9 Amphotericin B (AmB) is a conventional antifungal drug belonging to the macrolide class.…”

Section: Introductionmentioning

confidence: 99%

Micelle-like Nanoassemblies of Short Peptides Create Antimicrobial Selectivity in a Conventional Antifungal Drug

Morita

Nishimura

Ishii

et al. 2022

ACS Appl. Nano Mater.

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The discovery of novel antibacterial drugs against infectious diseases has decreased over the past few decades because of their poor cost performance. In this study, we report that the nanoassembly of a short-peptide hydrogelator (P1) endowed novel antifungal selectivity to a conventional antifungal drug, amphotericin B (AmB), which expands its application spectrum. Clinical use of AmB is limited because of poor water solubility and poor selectivity in its toxicity, which often causes harmful effects on tissues. P1 was the low-molecular-weight hydrogelator (LMWHg) that showed low cytotoxicity and was enzymatically degraded. In general, an LMWHg entraps foreign hydrophobic molecules inside the hydrophobic space in the self-assembled body. P1 successfully solubilized AmB in water as a form of a nanocomplex (NC) that had a chain-like structure. The NCs showed remarkably low toxicity toward Saccharomyces cerevisiae as a model fungus when compared with free AmB, meaning that P1 suppressed the antifungal activity of AmB via coassembly. The suppressed antifungal activity of AmB recovered when P1 in the NCs was degraded by a protease to liberate AmB from the coassembly with P1. P1 at a high concentration formed a hydrogel incorporating AmB (AmB-P1 gel), in which the antifungal activity of AmB was suppressed as well as that in the NC. The coassembly with AmB affected the morphology of the P1 self-assembly. While S. cerevisiae that did not secrete proteases formed a colony on the AmB-P1 gel, Aspergillus oryzae that secreted proteases did not grow on the AmB-P1 gel at all, resulting in the selective killing of the fungus. Because some of malignant, infectious fungi secrete proteases, the coassembly strategy of conventional antifungal drugs with self-assembling molecules should lead to "drug repositioning" of approved drugs in the health and medical fields.

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One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium tuberculosis

Cited by 10 publications

References 51 publications

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Micelle-like Nanoassemblies of Short Peptides Create Antimicrobial Selectivity in a Conventional Antifungal Drug

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