One-pot, three-component, catalyst-free synthesis of novel derivatives of pyrido-[2,3-d]pyrimidines under ultrasonic irradiations

Abstract

Novel derivatives of pyrido-[2,3-d] pyrimidines were synthesized via an efficient and catalyst-free one-pot three-component reaction of 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile, 6-amino-(ethylthio)pyrimidine-4(3H)-one and arylaldehydes under ultrasonic irradiations. This practical method furnished the desired pyridopyrimidines in high yields (79-89%) and shorter reaction times (25-40 min). GRAPHICAL ABSTRACT

Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

“…Notably, nearly 70% of marketed drugs contain heterocycles. 1 Oxazolidine rings are common pharmacophores that comprise potent antitumor tetrahydroisoquinoline-based natural products including quinocarcin (Fig. 1, I) and tetrazomine ( Fig.…”

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

“…In 2016, Barghi‐Lish and co‐authors [112] conducted a study in which they synthesized a variety of novel pyrido[2,3‐ d ] pyrimidine 120 derivatives using a one‐pot three‐component reaction. The reaction was carried out using both conventional heating at 120°C and ultrasonic irradiation at 80°C in ethylene glycol as the solvent.…”