One-pot α-nucleophilic fluorination of acetophenones in a deep eutectic solvent

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

“…[49] Moreover, if a mixture of TBAF·3H2O and ZnF2 was added to the reaction medium, the formed chlorinated acetophenone underwent nucleophilic substitution giving directly the corresponding α-fluoroacetophenones in a one-pot methodology (Scheme 5). [50] Scheme 5. One-pot fluorination of acetophenones.…”

Green Chemical Approach: Low-Melting Mixture as a Green Solvent for Efficient Michael Addition of Homophthalimides with Chalcones

“…Infrared (IR) spectra were measured on a JASCO FT-IR 4100 spectrometer, with samples analyzed as KBr plates. 1 H and 13 C NMR spectral analyses were carried out on Bruker Avance Digital 400 and 100 MHz spectrometer in CDCl 3 , using TMS as an internal standard. High-resolution mass spectra (HRMS) were obtained using JEOL GC MATE II HRMS (EI) mass spectrometry.…”

“…In recent decades, low-melting mixtures are emerging as a promising medium for a wide range of organic transformations 1 and in other fields including extraction, battery, etc., which demonstrate their advantages, including high yield, ambient reaction conditions, and readily available renewable resources. 2 Abbott et al have demonstrated that the physical properties and phase behaviors of the low melting mixtures are closely associated with ionic liquids (ILs).…”

Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine

“…Synthesis of fluorinated derivatives of monocarbonyl compounds, such as ketones and aldehydes, are of high importance in fluoro-organic chemistry [110][111][112][113][114][115][116][117][118][119][120][121]. These types of fluorinated derivatives are of proven synthetic value as building blocks for the preparation of a variety of polyfunctional fluorine-containing compounds of biological interest [30,[122][123][124][125][126][127][128].…”