One-step biofabrication of copper nanoparticles from Aegle marmelos correa aqueous leaf extract and evaluation of its anti-inflammatory and mosquito larvicidal efficacy

Angajala, Gangadhara; Pavan, Pasupala; Subashini, R.

doi:10.1039/c4ra10003d

Cited by 60 publications

(32 citation statements)

References 38 publications

(32 reference statements)

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“…Plants and their related materials for production of nanomaterials are not only ecofriendly alternatives, but they are also cost effective. Synthesis of copper oxide (CuO) nanoparticles has been performed using extracts of soybeans [8], gum karaya [9], bark extract [10], leaf extract [11,12], fruit [13,14], tea and coffee powder [15], peel extract [16] and flower extract [17]. …”

Section: Introductionmentioning

confidence: 99%

Plant Mediated Green Synthesis of CuO Nanoparticles: Comparison of Toxicity of Engineered and Plant Mediated CuO Nanoparticles towards Daphnia magna

et al. 2016

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Research on green production methods for metal oxide nanoparticles (NPs) is growing, with the objective to overcome the potential hazards of these chemicals for a safer environment. In this study, facile, ecofriendly synthesis of copper oxide (CuO) nanoparticles was successfully achieved using aqueous extract of Pterospermum acerifolium leaves. P. acerifolium-fabricated CuO nanoparticles were further characterized by UV-Visible spectroscopy, field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and dynamic light scattering (DLS). Plant-mediated CuO nanoparticles were found to be oval shaped and well dispersed in suspension. XPS confirmed the elemental composition of P. acerifolium-mediated copper nanoparticles as comprised purely of copper and oxygen. DLS measurements and ion release profile showed that P. acerifolium-mediated copper nanoparticles were more stable than the engineered CuO NPs. Copper oxide nanoparticles are used in many applications; therefore, their potential toxicity cannot be ignored. A comparative study was performed to investigate the bio-toxic impacts of plant-synthesized and engineered CuO nanoparticles on water flea Daphnia. Experiments were conducted to investigate the 48-h acute toxicity of engineered CuO NPs and plant-synthesized nanoparticles. Lower EC50 value 0.102 ± 0.019 mg/L was observed for engineered CuO NPs, while 0.69 ± 0.226 mg/L was observed for plant-synthesized CuO NPs. Additionally, ion release from CuO nanoparticles and 48-h accumulation of these nano CuOs in daphnids were also calculated. Our findings thus suggest that the contribution of released ions from nanoparticles and particles/ions accumulation in Daphnia needs to be interpreted with care.

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Section: Introductionmentioning

confidence: 99%

Plant Mediated Green Synthesis of CuO Nanoparticles: Comparison of Toxicity of Engineered and Plant Mediated CuO Nanoparticles towards Daphnia magna

et al. 2016

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“…In recent past, the CuO NPs were synthesized from Acalypha indica (Sivaraj et al 2014), Aloe vera (Vijay Kumar et al 2015) and Punica granatum (Ghidana et al 2016). These nanoparticles exhibit different biological activities like, anticancer (Sankar et al 2014), anti-inflammatory, mosquito larvicidal (Angajala et al 2014), wound healing (Tiwari et al 2014), antimicrobial (Shende et al 2015), anti diabetic and antioxidant activity (Ghosh et al 2015). However, there is no report on green synthesis of CuO NPs from S. alternifolium and there is no validation of antimicrobial activity against microorganisms and anticancer activity against MDA-MB-231 breast cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired green synthesis of copper oxide nanoparticles from Syzygium alternifolium (Wt.) Walp: characterization and evaluation of its synergistic antimicrobial and anticancer activity

et al. 2017

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In recent times, nanoparticles are attributed to green nanotechnology methods to know the synergistic biological activities. To accomplish this phenomenon, present study was aimed to synthesize copper oxide nanoparticles (CuO NPs) by using Syzygium alternifolium stem bark, characterized those NPs using expository tools and to elucidate high prioritized antimicrobial and anticancer activities. Synthesized particles exhibited a color change pattern upon synthesis and affirmed its respective broad peak at 285 nm which was analyzed through UV-vis spectroscopy. FT-IR study confirmed that phenols and primary amines were mainly involved in capping and stabilization of nanoparticles. DLS and Zeta potential studies revealed narrow size of particles with greater stability. XRD studies revealed the crystallographic nature of particles with 17.2 nm average size. Microscopic analysis by using TEM revealed that particle size range from 5-13 nm and most of them were spherical in shape, non-agglomerated and poly-dispersed in condition. Antimicrobial studies of particles showed highest inhibitory activity against E. coli and T. harzianum among bacterial and fungal strains, respectively. The scope of this study is extended by examining anticancer activity of CuO NPs. This study exhibited potential anticancer activity towards MDA-MB-231 human breast cancer lines. Overall, these examinations relate that the S. alternifolium is described as efficient wellbeing plant and probabilistically for the design and synthesis of nanoparticles for human health. This study paves a way to better understand antimicrobial and anticancer therapeutic drug potentials of nanoparticles to design and analysis of pharmaceuticals by in vivo and in vitro approaches.

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“…AgNPs were also found to induce neuronal differentiation by modulating intracellular signaling pathways, thus there potential could be applied for stem cell research and therapy [113]. Antimalarial application of synthesized NPs is also widely acknowledged [54,114]. In a study, AgNPs synthesized from Catharanthus roseus directly inhibited the malaria parasite Plasmodium falciparum [115].…”

Section: Miscellaneous Applicationsmentioning

confidence: 97%

“…VITDDK3 90 Cubic [50] Fungi Ganoderma spp. 20 Spherical [19] Green algae Prasiola crispa 9.8 Face-centred cubic [51] Biomolecule Ascorbic acid 20-25 Spherical [52] Nickel Plant Aegle marmelos Correa 80-100 Face centred cubic [53] Copper Plant Aegle marmelos Correa 50-100 Face centred cubic [54] Biomolecule Ascorbic acid and chitosan 100 Nd [55] Lead Plant Jatropha curcas 10-12.5 Spherical [56] Palladium Plant Coffee and tea 20-60 Face centred cubic [57] Selenium Bacteria Bacillus subtilis 50-400 Spherical [58] P3HB Bacteria Bacillus firmus 43.7 Nd [59] Magnetosome Bacteria Magnetospirillum gryphiswaldense 64-78 Spherical [60] Zinc oxide Plant Ocimum basilicum 50 Hexagonal [61] Bacteria Lactobacillus plantarum 7-19 Roughly spherical [62] Marine algae Sargassum muticum 30-57 Hexagonal wurtzite [63] Iron oxide Bacteria M. gryphiswaldense 24 Spherical [64] Biomolecule Starch 30-40 Spherical [31] Cadmium telluride Bacteria Escherichia coli 2.0-3.2 Spherical [65] Earthworm Lumbricus rubellus 2.3 Nearly spherical [66] Cadmium sulfide Plant Trigonella foenum graecum 53 Triangle [67] Lead selenide Marine microbe Aspergillus terreus 59 Rod [68] Silver chloride Plant Cissus quadrangularis 15-23 Spherical [69] Silver-gold Protein Macerase enzyme 4-20 Spherical [70] Plant Indian Rosewood 15-25 Spherical [71] Iron oxide-silver Plant Vitis vinifera 50 Spherical Reproduced with permission from [32]. © Elsevier (2013).…”

Section: Silver Plantmentioning

confidence: 99%

Green Synthesis of Therapeutic Nanoparticles: an Expanding Horizon

Kumar¹,

Lather²,

Pandita³

2015

Nanomedicine (Lond.)

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Nanotechnology continues to achieve tremendous awards in therapeutics, but the economical and ecofriendly production of nanoparticles (NPs) is still in infancy, simply due to the nanotoxicity, unprecedented health hazards and scale up issues. Green nanotechnology was introduced in the quest to mitigate such risks by utilizing natural resources as biological tool for NP synthesis. The key advantages offered by green approach include lower capital and operating expenses, reduced environmental impacts, superior biocompatibility and higher stability. In this review, we shed light on the biosynthesis of therapeutic NPs along with their numerous biomedical applications. Toxicity aspects of NPs and the impact of green approach on it, is also discussed briefly.

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One-step biofabrication of copper nanoparticles from Aegle marmelos correa aqueous leaf extract and evaluation of its anti-inflammatory and mosquito larvicidal efficacy

Abstract: Biofabrication of CuNps from AmC aqueous leaf extract of various sizes with good anti-inflammatory and mosquito larvicidal efficacy.

Cited by 60 publications

References 38 publications

Plant Mediated Green Synthesis of CuO Nanoparticles: Comparison of Toxicity of Engineered and Plant Mediated CuO Nanoparticles towards Daphnia magna

Plant Mediated Green Synthesis of CuO Nanoparticles: Comparison of Toxicity of Engineered and Plant Mediated CuO Nanoparticles towards Daphnia magna

Bioinspired green synthesis of copper oxide nanoparticles from Syzygium alternifolium (Wt.) Walp: characterization and evaluation of its synergistic antimicrobial and anticancer activity

Green Synthesis of Therapeutic Nanoparticles: an Expanding Horizon

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